Cómo citar
Camacho, J. H., Rusinky Pinilla, L., Salazar Peña, D., Sanabria Dueñas, S., Rojas Carvajal, D., Burbano Castillo, N., Ruiz Peña, R., Palacino Saenz, I., Martínez Quesada, S., García Salazar, A., & Abdala Galvis, N. (2020). Microbiota intestinal en pediatría . Revista Repertorio De Medicina Y Cirugía, 2-9. https://doi.org/10.31260/RepertMedCir.01217372.1100

Autores/as

Jhon Hadersson Camacho
Sanitas
Liliana Rusinky Pinilla
Bio
David Salazar Peña
Bio
Santiago Sanabria Dueñas
Bio
David Rojas Carvajal
Bio
Niko Burbano Castillo
Bio
Rubén Ruiz Peña
Bio
Isabella Palacino Saenz
Bio
Stefanny Martínez Quesada
Bio
Alejandro García Salazar
Bio
Nisrin Abdala Galvis
Bio

Resumen

La microbiota intestinal es el conjunto de millones de microrganismos vivos ubicados en el tracto gastrointestinal. Es indispensable en múltiples funciones del organismo, regulación de la inmunidad, en aspectos nutricionales y procesos de inflamación sistémica entre otros. La disbiosis es la alteración del equilibrio de la microbiota normal, debido a cambios en la composición, funcionamiento, orden o su distribución; esto puede predisponer al individuo a la adquisición de enfermedades gastrointestinales, alérgicas y metabólicas, entre otras. El objetivo del presente artículo es realizar una revisión narrativa de la literatura sobre los conceptos claves de la microbiota intestinal, sus asociaciones fisiopatológicas con desórdenes gastrointestinales, alérgicos y metabólicos en pediatría.

Licencia

Citas

1. Icaza-Chávez M. Microbiota intestinal en la salud y la enfermedad. Revista de Gastroenterología de México. 2013;78(4):240-8. doi: 10.1016/j.rgmx.2013.04.004

2. Serrano C, Harris P. Desarrollo del microbioma intestinal en niños. Impacto en salud y enfermedad. Revista Chilena de Pediatría. 2016;87(3):151-3. doi: 10.1016/j.rchipe.2016.04.002

3. Pawankar R, Canonica GW, Holgate ST, Lockey RF. Libro Blanco sobre Alergia de la WAO. Resumen Ejecutivo. Tokyo: World Allergy Organization; 2011. p. 26.

4. González P, Arancibia J. La marcha atópica. Revista neumología pediátrica. 2006;3(1):124-8.

5. Simon RA. The allergy-asthma connection. Allergy and asthma proceedings. 2002;23(4):219-22. Epub 2002/09/12.

6. Perez-Munoz ME, Arrieta MC, Ramer-Tait AE, Walter J. A critical assessment of the "sterile womb" and "in utero colonization" hypotheses: implications for research on the pioneer infant microbiome. Microbiome. 2017;5(1):48. doi: 10.1186/s40168-017-0268-4

7. Weber TK, Polanco I. Gastrointestinal microbiota and some children diseases: a review. Gastroenterology research and practice. 2012;2012:676585. doi: 10.1155/2012/676585.

8. Tanaka S, Kamiya K, Hamazaki N, Matsuzawa R, Nozaki K, Maekawa E, et al. Utility of SARC-F for Assessing Physical Function in Elderly Patients With Cardiovascular Disease. Journal of the American Medical Directors Association. 2017;18(2):176-81. doi: 10.1016/j.alit.2017.07.010

9. Plaza-Diaz J, Fontana L, Gil A. Human Milk Oligosaccharides and Immune System Development. Nutrients. 2018;10(8). doi: 10.3390/nu10081038

10. Moreno Villares J. Flora bacteriana intestinal. Anales de Pediatría. 2016;4(1):12-9.

11. Mulligan CM, Friedman JE. Maternal modifiers of the infant gut microbiota: metabolic consequences. J Endocrinol. 2017;235(1):R1-R12. doi: 10.1530/JOE-17-0303

12. Neu J, Rushing J. Cesarean versus vaginal delivery: long-term infant outcomes and the hygiene hypothesis. Clin Perinatol. 2011;38(2):321-31. doi: 10.1016/j.clp.2011.03.008

13. Chong CYL, Bloomfield FH, O'Sullivan JM. Factors Affecting Gastrointestinal Microbiome Development in Neonates. Nutrients. 2018;10(3). doi: 10.3390/nu10030274

14. Li M, Wang M, Donovan SM. Early development of the gut microbiome and immune-mediated childhood disorders. Semin Reprod Med. 2014;32(1):74-86. doi: 10.1055/s-0033-1361825

15. Azad MB, Kozyrskyj AL. Perinatal programming of asthma: the role of gut microbiota. Clinical & developmental immunology. 2012;2012:932072. doi: 10.1155/2012/932072

16. Power SE, O'Toole PW, Stanton C, Ross RP, Fitzgerald GF. Intestinal microbiota, diet and health. Br J Nutr. 2014;111(3):387-402. doi: 10.1017/S0007114513002560

17. Chung KF. Airway microbial dysbiosis in asthmatic patients: A target for prevention and treatment? J Allergy Clin Immunol. 2017;139(4):1071-81. doi: 10.1016/j.jaci.2017.02.004

18. García Rivero J. Actualización en el conocimiento del microbioma en el asma. Rev Asma. 2017;2(2):179-86.

19. Gallo RL, Hooper LV. Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol. 2012;12(7):503-16. doi: 10.1038/nri3228

20. Pasparakis M, Haase I, Nestle FO. Mechanisms regulating skin immunity and inflammation. Nat Rev Immunol. 2014;14(5):289-301. doi: 10.1038/nri3646

21. Zhang LJ, Guerrero-Juarez CF, Hata T, Bapat SP, Ramos R, Plikus MV, et al. Innate immunity. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection. Science. 2015;347(6217):67-71. doi: 10.1126/science.1260972

22. Chehoud C, Rafail S, Tyldsley AS, Seykora JT, Lambris JD, Grice EA. Complement modulates the cutaneous microbiome and inflammatory milieu. Proc Natl Acad Sci U S A. 2013;110(37):15061-6. doi: 10.1073/pnas.1307855110

23. Liu YJ, Soumelis V, Watanabe N, Ito T, Wang YH, Malefyt Rde W, et al. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol. 2007;25:193-219. doi: 10.1146/annurev.immunol.25.022106.141718

24. Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, et al. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature. 2011;477(7363):229-33. doi: 10.1038/nature10329

25. Bjerkan L, Schreurs O, Engen SA, Jahnsen FL, Baekkevold ES, Blix IJ, et al. The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide. Mucosal immunol. 2015;8(1):49-56. doi: 10.1038/mi.2014.41

26. Yockey LJ, Demehri S, Turkoz M, Turkoz A, Ahern PP, Jassim O, et al. The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. J Invest Dermatol. 2013;133(12):2714-21. doi: 10.1038/jid.2013.228

27. Jaramillo-Rodríguez O, González-Correa C. Probióticos en prevención primaria de la dermatitis atópica en infantes con riesgo de padecerla: metanálisis. Biosalud. 2013;12(1):18-28.

28. Guarner F. Microbiota intestinal y enfermedades inflamatorias del intestino. Gastroenterología y Hepatología. 2011;34(3):147-54.

29. Sartor RB. Genetics and environmental interactions shape the intestinal microbiome to promote inflammatory bowel disease versus mucosal homeostasis. Gastroenterology. 2010;139(6):1816-9. doi: 10.1053/j.gastro.2010.10.036

30. Abreu MT, Vora P, Faure E, Thomas LS, Arnold ET, Arditi M. Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. J Immunol. 2001;167(3):1609-16. doi: 10.4049/jimmunol.167.3.1609

31. Boirivant M, Marini M, Di Felice G, Pronio AM, Montesani C, Tersigni R, et al. Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis. Gastroenterology. 1999;116(3):557-65. doi: 10.1016/S0016-5085(99)70177-0

32. Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, Wirtz S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med. 2000;6(5):583-8. doi: 10.1038/75068

33. Mupsilonller MJ, Paul T, Seeliger S. Necrotizing enterocolitis in premature infants and newborns. J Neonatal Perinatal Med. 2016;9(3):233-42. doi: 10.3233/NPM-16915130

34. Luca F, Kupfer SS, Knights D, Khoruts A, Blekhman R. Functional Genomics of Host-Microbiome Interactions in Humans. Trends Genet. 2018;34(1):30-40. doi: 10.1016/j.tig.2017.10.001

35. Davenport ER, Cusanovich DA, Michelini K, Barreiro LB, Ober C, Gilad Y. Genome-Wide Association Studies of the Human Gut Microbiota. PloS one. 2015;10(11):e0140301. doi: 10.1371/journal.pone.0140301

36. Goodrich JK, Waters JL, Poole AC, Sutter JL, Koren O, Blekhman R, et al. Human genetics shape the gut microbiome. Cell. 2014;159(4):789-99. doi: 10.1016/j.cell.2014.09.053

37. Wang J, Jia H. Metagenome-wide association studies: fine-mining the microbiome. Nat Rev Microbiol. 2016;14(8):508-22. doi: 10.1038/nrmicro.2016.83

38. Genética médica blog [Internet]. Valencia: Medigene Press 2019 [citado 2019 junio 9]; Disponible en: https://revistageneticamedica.com/blog/microbiota-humana/

39. Goodrich JK, Davenport ER, Clark AG, Ley RE. The Relationship Between the Human Genome and Microbiome Comes into View. Annu Rev Genet. 2017;51:413-33 doi: 10.1146/annurev-genet-110711-155532

40. Daza W, Dadán S, Higuera M. Microbiota intestinal y sobrecrecimiento bacteriano. CCAP. 2016;15(1):49-60.

41. Campuzano-Maya G. Pruebas de aliento basadas en hidrógeno. Medicina & Laboratorio. 2009;15(9-10):431-55.

42. Rodicio MdR, Mendoza MdC. Identificación bacteriana mediante secuenciación del ARNr 16S: fundamento, metodología y aplicaciones en microbiología clínica. Enfermedades Infecciosas y Microbiología Clínica. 2004;22(4):238-45.

43. Haak BW, Prescott HC, Wiersinga WJ. Therapeutic Potential of the Gut Microbiota in the Prevention and Treatment of Sepsis. Front Immunol. 2018;9:2042. doi: 10.3389/fimmu.2018.02042

44. Zeng H, Lazarova DL, Bordonaro M. Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention. World J Gastrointest Oncol. 2014;6(2):41-51. doi: 10.4251/wjgo.v6.i2.41

45. Castañeda Guillot C. Microbiota intestinal y salud infantil. Rev Cubana Pediatr. 2018;90(1):10-9.

46. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506-14. doi: 10.1038/nrgastro.2014.66

47. Coeuret V, Gueguen M, Vernoux JP. Numbers and strains of lactobacilli in some probiotic products. Int J Food Microbiol. 2004;97(2):147-56. doi: 10.1016/j.ijfoodmicro.2004.04.015

48. More MI, Swidsinski A. Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis - a review. Clinical and experimental gastroenterology. 2015;8:237-55. doi: 10.2147/CEG.S85574

49. Cameron D, Hock QS, Kadim M, Mohan N, Ryoo E, Sandhu B, et al. Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region. World J Gastroenterol. 2017;23(45):7952-64. doi: 10.3748/wjg.v23.i45.7952

50. Mitmesser S, Combs M. Prebiotics: Inulin and Other Oligosaccharides. In: Floch MH, Ringel Y, Walker WA, editors. The Microbiota in Gastrointestinal Pathophysiology : Implications for Human Health, Prebiotics, Probiotics, and Dysbiosis: Elsevier; 2017. p. 201-8.

51. Schrezenmeir J, de Vrese M. Probiotics, prebiotics, and synbiotics--approaching a definition. Am J Clin Nutr. 2001;73(2 Suppl):361S-4S. doi: 10.1093/ajcn/73.2.361s

52. Valdovinos MA, Montijo E, Abreu AT, Heller S, González-Garay A, Bacarreza D, et al. Consenso mexicano sobre probióticos en gastroenterología. Revista de Gastroenterología de México. 2017;82(2):156-78. doi: 10.1016/j.rgmx.2016.08.004

53. Markowiak P, Slizewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients. 2017;9(9). doi: 10.3390/nu9091021

54. Posada Bustos S, Vera Chamorro JF. Probióticos en diarrea aguda, asociada a antibióticos y nosocomial: evidencia en pediatría. Rev Col Gastroenterol. 2018;33(1):41-8.

55. Zhou H, Li S, Chen Y, Zhang Q, Bai X, Zhu C, et al. Evaluation of Streptococcus thermophilus IFFI 6038 Microcapsules Prepared Using an Ultra-fine Particle Processing System. AAPS PharmSciTech. 2018;19(3):1020-8. doi: 10.1208/s12249-017-0907-x

56. Preston K, Krumian R, Hattner J, de Montigny D, Stewart M, Gaddam S. Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. Beneficial microbes. 2018;9(5):697-706. doi: 10.3920/BM2017.0105

57. Bozzi Cionci N, Baffoni L, Gaggia F, Di Gioia D. Therapeutic Microbiology: The Role of Bifidobacterium breve as Food Supplement for the Prevention/Treatment of Paediatric Diseases. Nutrients. 2018;10(11). doi: 10.3390/nu10111723

58. Frohmader TJ, Chaboyer WP, Robertson IK, Gowardman J. Decrease in frequency of liquid stool in enterally fed critically ill patients given the multispecies probiotic VSL#3: a pilot trial. Am J Crit Care. 2010;19(3):e1-11. doi: 10.4037/ajcc2010976

59. Ianiro G, Rizzatti G, Plomer M, Lopetuso L, Scaldaferri F, Franceschi F, et al. Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2018;10(8). doi: 10.3390/nu10081074

60. Olsen R, Greisen G, Schroder M, Brok J. Prophylactic Probiotics for Preterm Infants: A Systematic Review and Meta-Analysis of Observational Studies. Neonatology. 2016;109(2):105-12. doi: 10.1159/000441274

61. Sung V, D'Amico F, Cabana MD, Chau K, Koren G, Savino F, et al. Lactobacillus reuteri to Treat Infant Colic: A Meta-analysis. Pediatrics. 2018;141(1). doi: 10.1542/peds.2017-1811

62. Ramani S, Stewart CJ, Laucirica DR, Ajami NJ, Robertson B, Autran CA, et al. Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection. Nature communications. 2018;9(1):5010. doi: 10.1038/s41467-018-07476-4

Descargas

La descarga de datos todavía no está disponible.
Coordinador Editorial

Leonardo Arismendy Rodriguez
jlarismendy@fucsalud.edu.co
Fundación Universitaria de Ciencias de la Salud - FUCS
Bogotá DC, Colombia
Dirección: Carrera 19 No. 8 A 32
Tel: (+571) 3538100 Ext. 2836

Asistente Editorial

Gloria Restrepo B.
revista.repertorio@fucsalud.edu.co
Fundación Universitaria de Ciencias de la Salud - FUCS
Bogotá DC, Colombia
Dirección: Carrera 19 No. 8 A 32
Tel: (+571) 3538100 Ext. 2836


Vigilada Mineducación

Sistema OJS 3 - Metabiblioteca |