Gliomas difusos en áreas elocuentes: avances diagnósticos y terapéuticos
Diffuse gliomas within eloquent areas: diagnostic and therapeutic advances
Barra lateral del artículo
PDF
FLIP
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
Contenido principal del artículo
Resumen
Objetivo: presentar los avances diagnósticos, moleculares y radiológicos, así como en las estrategias terapéuticas para gliomas difusos en los últimos 5 años (2018-2023) en la Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá D.C., Colombia. Materiales y métodos: se describen las técnicas diagnósticas y terapéuticas utilizadas para gliomas difusos con casos ilustrativos. Resultados: se muestran los avances de las herramientas diagnósticas y terapéuticas para el manejo de gliomas difusos. Discusión: en los últimos 5 años se ha avanzado en la clasificación, diagnóstico y tratamiento de los gliomas difusos, gracias a los avances tecnológicos como los marcadores moleculares, la tractografía y la fusión de imágenes para la neuronavegación y las técnicas de estimulación cortical. Esto ha permitido que el tratamiento de los pacientes con dichos tumores mejore la tasa de morbilidad, la calidad de vida libre de enfermedad y la supervivencia global. Conclusiones: las técnicas de diagnóstico como la tractografía, la fusión integral de imágenes intraoperatorias y el mapeo cerebral electrofisiológico con estimulación cortical y subcortical han mejorado el diagnóstico y tratamiento de los gliomas difusos.
Palabras clave:
Descargas
Detalles del artículo
Referencias
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, et al. Glioma. Nat Rev Dis Primers. 2015;1:15017. https://doi.org/10.1038/nrdp.2015.17
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021;23(8):1231-1251. https://doi.org/10.1093/neuonc/noab106.
Ordonez-Rubiano EG, Johnson J, Enciso-Olivera CO, Marin-Munoz JH, Cortes-Lozano W, Baquero-Herrera PE, et al. Reconstruction of the Ascending Reticular Activating System with Diffusion Tensor Tractography in Patients with a Disorder of Consciousness after Traumatic Brain Injury. Cureus. 2017;9(9):e1723. https://doi.org/10.7759/cureus.1723.
Ordonez-Rubiano EG, Valderrama-Arias FA, Forbes JA, Johnson JM, Younus I, Marin-Munoz JH, et al. Identification of Preoperative Language Tracts for Intrinsic Frontotemporal Diseases: A Pilot Reconstruction Algorithm in a Middle-Income Country. World Neurosurg. 2019;125:e729-e742. https://doi.org/10.1016/j.wneu.2019.01.163.
Parra-Morales AM, Rudas J, Vargas JA, Gomez F, Enciso-Olivera CO, Trujillo-Rodriguez D, et al. Structural and functional connectivity of ascending reticular activating system in a patient with impaired consciousness after a cardiac arrest: A case report. Medicine (Baltimore). 2019;98(19):e15620. https://doi.org/10.1097/MD.0000000000015620.
Enciso-Olivera CO, Ordonez-Rubiano EG, Casanova-Libreros R, Rivera D, Zarate-Ardila CJ, Rudas J, et al. Structural and functional connectivity of the ascending arousal network for prediction of outcome in patients with acute disorders of consciousness. Sci Rep. 2021;11(1):22952. https://doi.org/10.1038/s41598-021-98506-7.
Abdala-Vargas NJ, Umana GE, Patino-Gomez JG, Ordonez-Rubiano E, Cifuentes-Lobelo HA, Palmisciano P, et al. Standardization of Strategies to Perform a Parafascicular Tubular Approach for the Resection of Brain Tumors in Eloquent Areas. Brain Sci. 2023;13(3):498. https://doi.org/10.3390/brainsci13030498.
Penfield W, Baldwin M. Temporal lobe seizures and the technic of subtotal temporal lobectomy. Ann Surg. 1952;136(4):625-634.
Spencer DD, Spencer SS. Surgery for epilepsy. Neurol Clin. 1985;3(2):313-330.
Vadera S, Kshettry VR, Klaas P, Bingaman W. Seizure-free and neuropsychological outcomes after temporal lobectomy with amygdalohippocampectomy in pediatric patients with hippocampal sclerosis. J Neurosurg Pediatr. 2012;10(2):103-107. https://doi.org/10.3171/2012.4.PEDS1233.
Yeh FC, Zaydan IM, Suski VR, Lacomis D, Richardson RM, Maroon JC, et al. Differential tractography as a track-based biomarker for neuronal injury. Neuroimage. 2019;202:116131. https://doi.org/10.1016/j.neuroimage.2019.116131.
Henderson F, Abdullah KG, Verma R, Brem S. Tractography and the connectome in neurosurgical treatment of gliomas: the premise, the progress, and the potential. Neurosurg Focus. 2020;48(2):E6. https://doi.org/10.3171/2019.11.FOCUS19785.
Duffau H. Surgical neurooncology is a brain networks surgery: a "connectomic" perspective. World Neurosurg. 2014;82(3-4):e405-7. https://doi.org/10.1016/j.wneu.2013.02.051.
Jensen JH, Helpern JA, Ramani A, Lu H, Kaczynski K. Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med. 2005;53(6):1432-40. https://doi.org/10.1002/mrm.20508.
Khalsa SSS, Hollon TC, Adapa A, Urias E, Srinivasan S, Jairath N, et al. Automated histologic diagnosis of CNS tumors with machine learning. CNS Oncol. 2020;9(2):CNS56. https://doi.org/10.2217/cns-2020-0003.
Li YC, Chiu HY, Lin YJ, Chen KT, Hsu PW, Huang YC, et al. The Merits of Awake Craniotomy for Glioblastoma in the Left Hemispheric Eloquent Area: One Institution Experience. Clin Neurol Neurosurg. 2021;200:106343. https://doi.org/10.1016/j.clineuro.2020.106343.
Hervey-Jumper SL, Li J, Lau D, Molinaro AM, Perry DW, Meng L, et al. Awake craniotomy to maximize glioma resection: methods and technical nuances over a 27-year period. J Neurosurg. 2015;123(2):325-39. https://doi.org/10.3171/2014.10.JNS141520.
Zhang JJY, Lee KS, Voisin MR, Hervey-Jumper SL, Berger MS, Zadeh G. Awake craniotomy for resection of supratentorial glioblastoma: a systematic review and meta-analysis. Neurooncol Adv. 2020;2(1):vdaa111. https://doi.org/10.1093/noajnl/vdaa111.
Orringer DA, Pandian B, Niknafs YS, Hollon TC, Boyle J, Lewis S, et al. Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy. Nat Biomed Eng. 2017;1: 0027. https://doi.org/10.1038/s41551-016-0027.
Jonsson P, Lin AL, Young RJ, DiStefano NM, Hyman DM, Li BT, et al. Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas. Clin Cancer Res. 2019;25(18):5537-5547. https://doi.org/10.1158/1078-0432.CCR-19-0032.
Lv H, Wang Z, Tong E, Williams LM, Zaharchuk G, Zeineh M, et al. Resting-State Functional MRI: Everything That Nonexperts Have Always Wanted to Know. AJNR Am J Neuroradiol. 2018;39(8):1390-1399. https://doi.org/10.3174/ajnr.A5527.
Cargnelutti E, Ius T, Skrap M, Tomasino B. What do we know about pre- and postoperative plasticity in patients with glioma? A review of neuroimaging and intraoper ative mapping studies. Neuroimage Clin. 2020;28:102435. https://doi.org/10.1016/j.nicl.2020.102435.