Cómo citar
Baracaldo Ayala, R. L., Peña Carvajalino, L. F., Gómez Rodríguez, O., Nieto, J. F. P., López Correa, P., & Medina, R. P. (2020). Características histopatológicas del carcinoma colorrectal con inestabilidad microsatelital (IMS). Revista Repertorio De Medicina Y Cirugía, 29(1). https://doi.org/10.31260/RepertMedCir.v29.n1.2020.172

Autores/as

Rafael Leonardo Baracaldo Ayala
Fundación Universitaria Ciencias de la Salud
Laura Felisa Peña Carvajalino
Fundación Universitaria Ciencias de la Salud
Omar Gómez Rodríguez
Fundación Universitaria Ciencias de la Salud
José Fernando Polo Nieto
Hospital de San José
Patricia López Correa
Fundación Universitaria Ciencias de la Salud
Rafael Parra Medina
Fundación Universitaria Ciencias de la Salud

Resumen

El carcinoma colorrectal es una de las neoplasias con mayor incidencia a nivel mundial. Algunos de los tipos de cáncer colorrectal tienen componente hereditario y asociación con defectos en la reparación génica a nivel replicacional por mutaciones en los genes encargados (MLH1, MSH2, MSH6 y PMS2) llamándose esto la inestabilidad microsatélite. Esta situación se acompaña de mayor predisposición a desarrollar carcinoma colorrectal y carcinomas extracolónicos que incluyen cáncer de estómago, endometrio, ovarios, tracto urinario, entre otros. Es importante, entonces, evaluar la presencia de la inestabilidad microsatélite a nivel histopatológico conociendo que hay algunos hallazgos que hacen sospechar la presencia de estas alteraciones genéticas, tales como la presencia de linfocitos intraepiteliales, infiltrado inflamatorio Crohn-like, el subtipo histológico y la localización. El objetivo de este artículo es revisar en detalle algunas características de las variables mencionadas, así como de resaltar la importancia de otras variables histopatológicas con impacto pronóstico.

Licencia

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Coordinador Editorial

Leonardo Arismendy Rodriguez
jlarismendy@fucsalud.edu.co
Fundación Universitaria de Ciencias de la Salud - FUCS
Bogotá DC, Colombia
Dirección: Carrera 19 No. 8 A 32
Tel: (+571) 3538100 Ext. 2836

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Gloria Restrepo B.
revista.repertorio@fucsalud.edu.co
Fundación Universitaria de Ciencias de la Salud - FUCS
Bogotá DC, Colombia
Dirección: Carrera 19 No. 8 A 32
Tel: (+571) 3538100 Ext. 2836


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