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Proteína moduladora de la actividad del receptor de aril hidrocarburos (AIP): genética, bioquímica e impacto clínico

Aryl hydrocarbon receptor interacting protein (AIP): genetics, biochemistry and clinical impact




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Florez Romero , A. ., Rojas , W. ., Reverend L. , C. ., Torres , L. ., & Quintero , G. . (2021). Proteína moduladora de la actividad del receptor de aril hidrocarburos (AIP): genética, bioquímica e impacto clínico. Revista Repertorio De Medicina Y Cirugía, 30(1), 13-21. https://doi.org/10.31260/RepertMedCir.01217273.888

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Andres Florez Romero
    William Rojas
      Carlos Reverend L.
        Lilian Torres
          Gloria Quintero

            Andres Florez Romero ,

            Medina Interna, Endocrinólogía. Fundación Universitaria de Ciencias de la Salud. Bogotá DC, Colombia.


            William Rojas ,

            Servicio de Endocrinología, Hospital de San José. Fundación Universitaria de Ciencias de la Salud. Bogotá DC, Colombia.


            Carlos Reverend L. ,

            Grupo de Ciencias Básicas en Salud. Fundación Universitaria de Ciencias de la Salud. Bogotá DC, Colombia.


            Lilian Torres ,

            Grupo de Ciencias Básicas en Salud. Fundación Universitaria de Ciencias de la Salud. Bogotá DC, Colombia.


            Gloria Quintero ,

            Medicina Interna. Fundación Universitaria de Ciencias de la Salud. Bogotá DC, Colombia.


            El gen AIP (proteína moduladora de la actividad del receptor de aril hidrocarburos) se localiza en la región 11q13.2 y codifica para una proteína de 330 aminoácidos que interactúa con el factor de transcripción AhR (receptor para aril hidrocarburos). Las mutaciones en este gen se han asociado con adenomas pituitarios aislados de tipo familiar (APAF). Se caracterizan por una presentación temprana (alrededor de 20 años), por lo regular producen hormona de crecimiento y/o prolactina, tienen un comportamiento clínico agresivo y poca respuesta a análogos de somatostatina.


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