Postoperative calcium metabolism disorders after thyroidectomy
Trastornos posoperatorios del metabolismo del calcio postiroidectomía
Show authors biography
Introduction: narrative review revealing how the practice of thyroidectomy alongside with hypocalcemia and hypoparathyroidism, its complications, has increased in recent years. Methods: searches in the PubMed, Clinical Key, Embase, Cochrane and Lilacs databases; references in Spanish and English, published between 2016 and 2020 were included. The selected articles were reviewed using CONSORT, STROBE or PRISMA, as appropriate. Results: 35 articles directly related with the topic were selected, including meta-analyses, systematic reviews, prospective and observational studies, narrative reviews and expert consensus, on all five continents. The two forms of hypocalcemia and hypoparathyroidism can result from devascularization or accidental removal of the parathyroid glands, patient-specific factors, or from the surgical technique or the pathological characteristics of the thyroid lesion. Preventive strategies include the use of optical tools for preoperative determination of parathyroid glands location; as well as the possibility of autotransplantation after confirming parathyroid tissue in the biopsy specimen. The best marker of calcium metabolism is iPTH. Conclusions: preservation of the parathyroid glands and their irrigation is the best strategy to prevent postoperative calcium disorders.
Article visits 941 | PDF visits 596
Downloads
- Kohnen B, Schürmeyer C, Schürmeyer TH, Kress P. Surgery of benign thyroid disease by ENT/head and neck surgeons and general surgeons: 233 cases of vocal fold paralysis in 3509 patients. Eur Arch Oto-Rhino-Laryngology. 2018;275(9):2397–402. doi: 10.1007/s00405-018-5077-2
- Sun GH, Demonner S, Davis MM. Epidemiological and economic trends in inpatient and outpatient thyroidectomy in the United States, 1996-2006. Thyroid. 2013;23(6):727–33.
- International Agency for Research on Cancer. Cancer today [Internet]. Lyon: World Health Organization; 2020 [cited 2020 marzo 29]. Disponible en: https://gco.iarc.fr/today/home.
- Efremidou EI, Papageorgiou MS, Liratzopoulos N, Manolas KJ. The efficacy and safety of total thyroidectomy in the management of benign thyroid disease: A review of 932 cases. Can J Surg. 2009;52(1):39–44.
- Dedivitis RA, Aires FT, Cernea CR. Hypoparathyroidism after thyroidectomy: Prevention, assessment and management. Curr Opin Otolaryngol Head Neck Surg. 2017;25(2):142–6. doi: 10.1097/MOO.0000000000000346.
- Calvo Espino P, Rivera Bautista JÁ, Artés Caselles M, Serrano González J, García Pavía A, García-Oria MJ, et al. Serum levels of intact parathyroid hormone on the first day after total thyroidectomy as predictor of permanent hypoparathyroidism. Endocrinol Diabetes y Nutr. 2019;66(3):195–201. doi: 10.1016/j.endinu.2018.08.006
- Kakava K, Tournis S, Papadakis G, Karelas I, Stampouloglou P, Kassi E, et al. Postsurgical hypoparathyroidism: A systematic review. In Vivo (Brooklyn). 2016;30(3):171–80.
- Orloff LA, Wiseman SM, Bernet VJ, Fahey TJ, Shaha AR, Shindo ML, et al. American Thyroid Association Statement on Postoperative Hypoparathyroidism: Diagnosis, Prevention, and Management in Adults. 2018 Jul;28(7):830-841. doi: 10.1089/thy.2017.0309
- Schlottmann F, Arbulú ALC, Sadava EE, Mendez P, Pereyra L, Fernández Vila JM, et al. Algorithm for early discharge after total thyroidectomy using PTH to predict hypocalcemia: prospective study. Langenbeck’s Arch Surg. 2015;400(7):831–6. doi: 10.1007/s00423-015-1341-8
- Ponce de León-Ballesteros G, Velázquez-Fernández D, Hernández-Calderón FJ, Bonilla-Ramírez C, Pérez-Soto RH, Pantoja JP, et al. Hypoparathyroidism After Total Thyroidectomy: Importance of the Intraoperative Management of the Parathyroid Glands. World J Surg. 2019;43(7):1728-1735. doi: 10.1007/s00268-019-04987-z
- Wang B, Zhu CR, Liu H, Wu J. The effectiveness of parathyroid gland autotransplantation in preserving parathyroid function during thyroid surgery for thyroid neoplasms: A meta-analysis. PLoS One. 2019;14(8): e0221173. doi: 10.1371/journal.pone.0221173
- Harsløf T, Rolighed L, Rejnmark L. Huge variations in definition and reported incidence of postsurgical hypoparathyroidism: a systematic review. Endocrine [Internet]. 2019;64(1):176–83. doi: 10.1007/s12020-019-01858-4
- Iorio O, Petrozza V, De Gori A, Bononi M, Porta N, De Toma G, et al. Parathyroid Autotransplantation During thyroid Surgery. Where we are? A Systematic Review on Indications and Results. J Investig Surg. 2019;32(7):594–601. doi: 10.1080/08941939.2018.1441344
- Kazaure HS, Sosa JA. Surgical Hypoparathyroidism. Endocrinol Metab Clin North Am. 2018;47(4):783–96. doi: 10.1016/j.ecl.2018.07.005
- Teshima M, Otsuki N, Morita N, Furukawa T, Shinomiya H, Shinomiya H, et al. Postoperative hypoparathyroidism after total thyroidectomy for thyroid cancer. Auris Nasus Larynx. 2018;45(6):1233–8. doi: 10.1016/j.anl.2018.04.008
- Rosato L, Avenia N, De Palma M, Gulino G, Nasi PG, Pezzullo L. [Complications of total thyroidectomy: incidence, prevention and treatment]. Chir Ital. 2002;54(5):635–42.
- Shou JD, He SM, Jiang XF, Shi LH, Xie L, Wang JB, et al. Anatomical localization of normal parathyroid glands before thyroidectomy through ultrasonography reduces postoperative hypoparathyroidism. Med (United States). 2019;98(24): e16020. doi: 10.1097/MD.0000000000016020.
- Lombardi D, Accorona R, Paderno A, Cappelli C, Nicolai P. Morbidity of central neck dissection for papillary thyroid cancer. Gland Surg. 2017;6(5):492–500. doi: 10.21037/gs.2017.05.07
- Mejía, M. G.; Vega, M. P.; Hakim JH. Prevalencia de hipocalcemia postiroidectomía en cirugía de cáncer de tiroides. Rev Colomb Endocrinol Diabetes Metab. 2019;6(2):80–5.
- Wang YH, Bhandari A, Yang F, Zhang W, Xue LJ, Liu HG, et al. Risk factors for hypocalcemia and hypoparathyroidism following thyroidectomy: A retrospective Chinese population study. Cancer Manag Res. 2017;9:627–35. doi: 10.2147/CMAR.S148090
- Docimo G, Ruggiero R, Casalino G, del Genio G, Docimo L, Tolone S. Risk factors for postoperative hypocalcemia. Updates Surg. 2017;69(2):255–60. doi: 10.1007/s13304-017-0452-x
- Chew C, Li R, Ng MK, Chan STF, Fleming B. Incidental parathyroidectomy during total thyroidectomy is not a direct cause of post-operative hypocalcaemia. ANZ J Surg. 2018;88(3):158–61. doi: 10.1111/ans.13939
- Păduraru DN, Ion D, Carsote M, Andronic O, Bolocan A. Post-thyroidectomy Hypocalcemia - Risk Factors and Management. Chirurgia (Bucur). 2019;114(5):564-570. doi: 10.21614/chirurgia.114.5.564
- Philips R, Nulty P, Seim N, Tan Y, Brock G, Essig G. Predicting transient hypocalcemia in patients with unplanned parathyroidectomy after thyroidectomy. Am J Otolaryngol - Head Neck Med Surg. 2019;40(4):504–8. doi: 10.1016/j.amjoto.2019.04.006
- Abbaci M, De Leeuw F, Breuskin I, Casiraghi O, Lakhdar A Ben, Ghanem W, et al. Parathyroid gland management using optical technologies during thyroidectomy or parathyroidectomy: A systematic review. Oral Oncol. 2018;87:186–96. doi: 10.1016/j.oraloncology.2018.11.011
- Castro A, Oleaga A, Parente Arias P, Paja M, Gil Carcedo E, Álvarez Escolá C. Executive Summary of the SEORL CCC-SEEN Consensus Document on Post-thyroidectomy Hypoparathyroidism. Acta Otorrinolaringol. 2019;70(5):301–5. doi: 10.1016/j.otoeng.2019.08.002
- Sanabria Á, Domínguez LC, Vega V, Osorio C, Duarte D. Cost-effectiveness analysis regarding postoperative administration of vitamin-D and calcium after thyroidectomy to prevent hypocalcaemia. Rev Salud Pública. 2011;13(5):804–13.
- Sanabria A, Dominguez LC, Vega V, Osorio C, Duarte D. Routine postoperative administration of vitamin D and calcium after total thyroidectomy: A meta-analysis. Int J Surg. 2011;9(1):46–51. doi: 1016/j.ijsu.2010.08.006
- Chadwick DR. Hypocalcaemia and permanent hypoparathyroidism after total/bilateral thyroidectomy in the BAETS Registry. Gland Surg. 2017;6(Suppl 1):S69–74. doi: 10.21037/gs.2017.09.14
- Coudenys E, Meerhaeghe T Van, Unuane D, Buyl R, Bravenboer B. Long-Term Treatment with Calcitriol in Postsurgical Hypoparathyroidism Leads to Renal Function Decline. Horm Metab Res. 2019;51(6):362–6. doi: 10.1055/a-0902-8476
- Suwannasarn M, Jongjaroenprasert W, Chayangsu P, Suvikapakornkul R, Sriphrapradang C. Single measurement of intact parathyroid hormone after thyroidectomy can predict transient and permanent hypoparathyroidism: a prospective study. Asian J Surg. 2017;40(5):350–6. doi: 10.1016/j.asjsur.2015.11.005
- Díez Alonso M, Sánchez López JD, Sánchez-Seco Peña MI, Ratia Jiménez T, Arribas Gómez I, Rodríguez Pascual Á, et al. Serum PTH levels as a predictive factor of hypocalcaemia after total thyroidectomy. Cirugía Española (English Ed). 2009;85(2):96–102. doi: 10.1016/S2173-5077(09)70122-X