About delayed hemolytic transfusion reactions

Acerca de las reacciones hemolíticas tardías

Introducction: Delayed hemolytic transfusion reactions (DHTR) happen 24 hours, two weeks or up to 30 days post transfusion. Immunologic transfusion reactions may be febrile, anaphylactic and hemolytic. Hemolysis occurs as a response to foreign red-blood cells antigens, in patients, previously exposed to transfusions and pregnancy. Case presentation: Herein we review the case of a patient, admitted to Hospital de San José in Bogotá, who presented with a delayed hemolytic reaction, in whom the expression of Duffy and E antigens was documented, secondary to immunization related to previous blood transfusions.

1. Bashawri LA, Ahmed MS, El-Fawaz N, AL-Qatary AA, Ali Ahmed M. Red Cell Alloimmunization in Thalassaemia Patients Bahrain Medical Bulletin. 2005;27(2):1-6.
2. Rosse WF, Gallagher D, Kinney TR, Castro O, Dosik H, Moohr J, et al. Transfusion and alloimmunization in sickle cell disease. The Cooperative Study of Sickle Cell Disease. Blood. 1990;76(7):1431-7.
3. Brand A. Immunological complications of blood transfusions. Presse Med. 2016;45(7-8 Pt 2):e313-24. https://doi.org/10.1016/j.lpm.2016.06.024.
4. Technical Manual. 15 ed. United States: the AABB; 2005.
5. Bryant NJ. An Introduction to Immunohematology. 3 ed. Philadelphia: W.B. Saunders Company; 1994.
6. Linares G. Inmunohematología y Banco de Sangre. Inmunohematologia y transfusion: principios y procedimientos Venezuela: Cromotip; 1986.
7. International Society of Blood Transfusion. Blood Group Alleles. Names for RH (ISBT 004) Whorshop 2010 [Internet]. Amsterdam: International Society of Blood Transfusion; 2010 [cited 2020 febrero]; Available from: http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-bloodgroup-terminology/blood-group-terminology/blood-group-allele-terminology/.
8. Vásquez Rojas M, Castillo Espinosa D, Pavez Espinoza Y, Maldonado Rojas M, Mena Leiva A. Frecuencia de antígenos del sistema sanguíneo Rh y del sistema Kell en donantes de sangre. Rev Cubana Hematol Inmunol Hemoter. 2015;31(2):160-71.
9. Sanz J, Besses C, Vives J. Hematología clínica. 5 ed. España: Elsevier; 2006.
10. Flegel WA. The genetics of the Rhesus blood group system. Blood Transfus.sangue. 2007;5(2):50-7. https://doi.org/10.2450/2007.0011-07.
11. Daniels G, Reid ME. Blood groups: the past 50 years. Transfusion. 2010;50(2):281-9. https://doi.org/10.1111/j.1537-2995.2009.02456.x.
12. Dean L. The Duffy blood group. In: Dean L, editor. Blood Groups and Red Cell Antigens. United State: NCBI Bookshelf; 2005.
13. Łukasik E, Nowak I, Czerwinski M, Waśniowska K. Duffy blood group system – the frequency of Duffy antigen polymorphisms and novel mutations in the Polish population. Transfus Apheresis Science. 2019;58(2):156-161. https://doi.org/10.1016/j.transci.2018.12.020.
14. Neote K, Mak JY, Kolakowski LF, Jr., Schall TJ. Functional and biochemical analysis of the cloned Duffy antigen: identity with the red blood cell chemokine receptor. Blood. 1994;84(1):44-52. https://doi.org/10.1182/blood.V84.1.44.44