Prolactina cervicovaginal en la predicción de parto pretérmino

Martha Rondón-Tapia; Eduardo Reyna-Villasmil; Jorly Mejía Montilla; Nadia Reyna-Villasmil; Duly Torres-Cepeda; Andreina Fernandez-Ramírez

doi:10.31260/RepertMedCir.v27.n1.2018.127

Cervicovaginal prolactin in the prediction of birth preterm

Prolactina cervicovaginal en la predicción de parto pretérmino

Published 2018-04-17

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Vol. 27 No. 1 (2018): Janaury - April

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Research Article

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Rondón-Tapia, M., Reyna-Villasmil, E., Mejía Montilla, J., Reyna-Villasmil, N., Torres-Cepeda, D., & Fernandez-Ramírez, A. (2018). Cervicovaginal prolactin in the prediction of birth preterm. Journal of Medicine and Surgery Repertoire, 27(1), 18-23. https://doi.org/10.31260/RepertMedCir.v27.n1.2018.127

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https://doi.org/10.31260/RepertMedCir.v27.n1.2018.127

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Martha Rondón-Tapia

Central Hospital "Dr. Urquinaone. " Maracaibo Venezuela.

Eduardo Reyna-Villasmil

Gynecology and Obstetrics Service. Central Hospital "Dr. Urquinaone. " Maracaibo Venezuela.

Jorly Mejía Montilla

University of Zulia. Maracaibo state zulia. Venezuela.

Nadia Reyna-Villasmil

Gynecology and Obstetrics Service. Central Hospital "Dr. Urquinaone. " Maracaibo Venezuela.

Duly Torres-Cepeda

Service of Obstetrics and Gynecology, Maternity "Dr. Nerio Belloso ", Central Hospital" Dr. Urquinaona ", Maracaibo, Zulia State, Venezuela.

Andreina Fernandez-Ramírez

University of Zulia. Maracaibo state zulia. Venezuela.

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prolactin

cervicovagina

preterm delivery

predictio

Objective: To establish usefulness of cervicovaginal prolactin concentrations in second trimester for the prediction of preterm delivery. Methods: Cervicovaginal samples were taken between 24 and 28 weeks of pregnancy. All patients were followed until delivery and divided in group A (preterm delivery) and group B (term delivery). General characteristics, cervicovaginal prolactin concentrations and prognostic efficacy were evaluated. Results: The mean gestational age at cervicovaginal sample was 26.2 +/- 1.1 weeks in group A and 25.9 +/- 1.1 weeks in group B (p = ns). There were not found significant differences in maternal age, body mass index and history of preterm labor (p = ns). Group A patients (1.6 +/- 0.8 ng/mL) showed higher cervicovaginal prolactin concentrations than group B (0.5 +/- 0.3 ng/mL; p < 0.0001). A cut-off value of 1 ng/mL had a value under curve of 0.87 with a sensitivity of 73.1%, specificity of 91.6%, positive predictive value of 44.7% and negative predictive value of 97.3%. Conclusion: Cervicovaginal prolactin concentrations are useful for the prediction of preterm delivery.

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