Myocardial dyssynchrony in patients undergoing Myocardial dyssynchrony in patients undergoing gated SPECT and phase analysis gated SPECT and phase analysis

Disincronía miocárdica en pacientes sometidos a estudio de Spect gatillado y análisis de fase

Introduction: Myocardial perfusion gated SPECT (simple photon emission computed tomography) with phase analysis allows the assessment of mechanical dyssynchrony and ejection fraction, for prediction of response to cardiac resynchronization therapy. Objective: to describe myocardial dyssynchrony frequency and its relationship with SPECT results at Hospital de San José de Bogotá between May 2018 and February 2019. Methodology: cross-sectional study in patients aged over 18 years, with a less than 6 months electrocardiogram and gated SPECT. Sociodemographic data, cardiovascular history, electrocardiogram parameters and SPECT results were evaluated using descriptive statistics and multiple correspondence analysis. Results: five-hundred-thirty-nine patients with a mean age of 68 years were included, 59.8% had overweight and obesity, 47.7% were NYHA (New York Heart Association) functional class III and IV, 48.4% smokers and 26.9% diabetics; 48.1% received cardiac catheterization and 45.3% had history of acute myocardial infarction; left ventricular ejection fraction was < 50% in 31%. Dyssynchrony was determined with a >135° bandwidth; dyssynchrony was evidenced in 202 patients (37.5%) and was related to male gender, overweight, diabetes, smoking, acute myocardial infarction, stent placement, left ventricular ejection fraction <40% or 40%-50% and transient ischemic dilation (TID) >1.22 or 1.12-1.22. Discussion and conclusions:the new nuclear medicine phase analysis tool is feasible and useful to identify cardiac resynchronization therapy responders.

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