Endoscopic management of gastroesophageal reflux disease (GERD)

Manejo endoscópico de la enfermedad por reflujo gastroesofágico (ERGE)

Gastroesophageal reflux disease (GERD) occurs when gastric chyme refluxes back into the esophagus and changes from physiologic to symptomatic and pathologic. It is common worldwide and is difficult to diagnose due to the diversity of symptoms and presentations, making its therapeutic approach complex. Although there are multiple treatment options, proton pump inhibitors (PPIs) have been the mainstay of pharmacological management of GERD. Surgical treatment is described but is used in selected patients. Endoscopic therapy emerges as another option with similar indications as surgery, featuring the advantages of endoscopic procedures. Several endoluminal techniques have been described showing poor results, thus their generalized use has not been achieved.

1. Katzka DA, Pandolfino JE, Kahrilas PJ. Phenotypes of Gastroesophageal Reflux Disease: Where Rome, Lyon, and Montreal Meet. Clinic Gastroenterol Heepatol. 2020;18(4):767-76. https://doi.org/10.1016/j.cgh.2019.07.015
2. Páramo Hernández DB, Albis R, Galiano MT, Mendoza de Molano B, Rincón R, Pineda Ovalle LF, et al. Prevalencia de síntomas del reflujo gastroesofágico y factores asociados: una encuesta poblacional en las principales ciudades de Colombia. Rev. Colomb Gastroenterol. 2016;31(4):337-346. http://doi.org/10.22516/25007440.108
3. Katz PO, Dunbar KB, Schnoll-Sussman FH, Greer KB, Yadlapati R, Spechler SJ. ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. Am J Gastroenterol 2022;117(1):27-56. http://doi.org/10.14309/ajg.0000000000001538
4. Richter JE, Rubenstein JH. Presentation and Epidemiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):267-276. http://doi.org/10.1053/j.gastro.2017.07.045
5. Hani AC, Galindo A, Leguizamo A, Maldonado C, Páramo H D, Costa V, et al. Guía de práctica clínica para la enfermedad por reflujo gastroesofágico. Rev. Colomb Gastroenterol. 2015;30(Supl.1):1-8.
6. Mayor MA, Fernando HC. Endoluminal Approaches to Gastroesophageal Reflux Disease. Thorac Surg Clin. 2018;28(4):527-532. http://doi.org/10.1016/j.thorsurg.2018.07.008
7. Lo WK, Mashimo H. Critical Assessment of Endoscopic Techniques for Gastroesophageal Reflux Disease. J Clin Gastroenterol. 2015;49(9):720-724. http://doi.org/10.1097/mcg.0000000000000389
8. Wong HJ, Su B, Attaar M, Kuchta K, Stearns S, Linn JG, et al. Anti-reflux mucosectomy (ARMS) results in improved recovery and similar reflux quality of life outcomes compared to laparoscopic Nissen fundoplication. Surg Endosc. 2021;35:7174-82. http://doi.org/10.1007/s00464-020-08144-9
9. Inoue H, Ito H, Ikeda H, Sato C, Sato H, Phalanusitthepha C, et al. Anti-reflux mucosectomy for gastroesophageal reflux disease in the absence of hiatus hernia: a pilot study. Ann Gastroenterol. 2014;27(4):346-351.
10. Nicolau AE, Lobonţiu A, Constantinoiu S. New Minimally Invasive Endoscopic and Surgical Therapies for Gastroesophageal Reflux Disease (GERD). Chirurgia (Bucur). 2018;113(1):70-82. http://doi.org/10.21614/chirurgia.113.1.70
11. Kushner BS, Awad MM, Mikami DJ, Chand BB, Wai CJ, Murayama KM. Endoscopic treatments for GERD. Ann N Y Acad Sci. 2020;1482(1):121-129. http://doi.org/10.1111/nyas.14511
12. Richter JE, Kumar A, Lipka S, Miladinovic B, Velanovich V. Efficacy of Laparoscopic Nissen Fundoplication vs Transoral Incisionless Fundoplication or Proton Pump Inhibitors in Patients With Gastroesophageal Reflux Disease: A Systematic Review and Network Meta-analysis. Gastroenterology. 2018;154(5):1298-1308.e7. http://doi.org/10.1053/j.gastro.2017.12.021
13. Rouphael C, Padival R, Sanaka MR, Thota PN. Endoscopic Treatments of GERD. Curr Treat Options Gastroenterol. 2018;16(1):58-71. http://doi.org/10.1007/s11938-018-0170-6
14. Satodate H, Inoue H, Yoshida T, Usui S, Iwashita M, Fukami N, et al. Circumferential EMR of carcinoma arising in Barrett's esophagus: case report. Gastrointest Endosc. 2003;58(2):288-292. http://doi.org/10.1067/mge.2003.361
15. Satodate H, Inoue H, Fukami N, Shiokawa A, Kudo SE. Squamous reepithelialization after circumferential endoscopic mucosal resection of superficial carcinoma arising in Barrett's esophagus. Endoscopy. 2004;36(10):909-912.http://doi.org/10.1055/s-2004-825830
16. Monino L, Gonzalez JM, Vitton V, Barthet M. Antireflux mucosectomy band in treatment of refractory gastroesophageal reflux disease: a pilot study for safety, feasibility and symptom control. Endosc Int Open. 2020;8(2):E147-e54.http://doi.org/10.1055/a-1038-4012
17. Debourdeau A, Vitton V, Monino L, Barthet M, Gonzalez JM. Antireflux Mucosectomy Band (ARM-b) in Treatment of Refractory Gastroesophageal Reflux Disease After Bariatric Surgery. Obes Surg. 2020;30(11):4654-4658.http://doi.org/10.1007/s11695-020-04753-4
18. Sumi K, Inoue H, Kobayashi Y, Iwaya Y, Abad MRA, Fujiyoshi Y, et al. Endoscopic treatment of proton pump inhibitor-refractory gastroesophageal reflux disease with anti-reflux mucosectomy: Experience of 109 cases. Dig Endosc. 2021;33(3):347-354. http://doi.org/10.1111/den.13727
19. Inoue H, Tanabe M, de Santiago ER, Abad MRA, Shimamura Y, Fujiyoshi Y, et al. Anti-reflux mucosal ablation (ARMA) as a new treatment for gastroesophageal reflux refractory to proton pump inhibitors: a pilot study. Endosc Int Open. 2020;8(2):E133-E138. http://doi.org/10.1055/a-1031-9436