Immunomodulatory antibodies for cancer treatment

Anticuerpos inmunomoduladores en el tratamiento del cáncer

Immunomodulatory antibodies (MAbs) acquire the ability to alter the function of the immune system. Their effects on CTLA-4 and PD-1 receptors limit cellular activation, affecting T lymphocytes activity. The role of both receptors is to inhibit autoreactive immune cells not destroyed in the corresponding immune structures and to protect inflamed tissues. Tumors expressing these receptors evade immune cells recognition. MAbs block the receptors and enable lymphocytes to recognize and respond to neoplastic antigens. Research on MAbs drugs shows moderate efficacy in the treatment of some cases of advanced cancer. The combination of drugs has potentially synergistic mechanisms with positive results. Possible indicators of therapeutic success and the likelihood of reducing the adverse effects in clinical use, have yet to be established. The aim of this review was to analyze the roles and usefulness of immunomodulatory antibodies for cancer therapy.

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