Diffuse large Nodal B-Cell Lymphoma with skin involvement

Linfoma B difuso de célula grande nodal con afectación extranodal en piel

Introduction: diffuse large B-cell lymphoma (DLBCL) is an aggressive tumor of mature B lymphocytes and is the most frequent non-Hodgkin lymphoma variety. DLBCL can occur at nodal and/or extra-nodal sites; between 30 and 40% of cases occur in the latter location mostly in the gastrointestinal tract, followed by the skin. Cutaneous involvement in systemic DLBCL classifies the patient into a higher stage leading to an unfavorable prognosis. Case report: an elderly adult with tumor-like cutaneous lesions seen at the dermatology department of Hospital de San José in Bogotá, Colombia. Discussion and conclusions: cutaneous involvement in systemic DLBCL is common, however, cutaneous involvement as the first manifestation of DLBCL is reported in only 3%. Our case demonstrates that skin changes may be the key to suspect this systemic neoplasm. Thus, it is important to include a dermatologist in the multidisciplinary evaluation, to achieve an early diagnosis and provide timely treatment, impacting patient’s prognosis.

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