Therapeutic approach to sickle cell anemia

Enfoque terapéutico en anemia falciforme

Published 2025-05-30

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Soto Manzano, A. V. ., Córdoba García, S., Flórez Castaño, L. M., Uribe Ramírez, M., & Martínez Sánchez, L. M. (2025). Therapeutic approach to sickle cell anemia. Journal of Medicine and Surgery Repertoire. https://doi.org/10.31260/RepertMedCir.01217372.1553
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Anggy Valentina Soto Manzano
Pontifical Bolivarian University image/svg+xml
Roles:  
https://orcid.org/0000-0003-3386-6970

Santiago Córdoba García
Pontifical Bolivarian University image/svg+xml
Roles:  
https://orcid.org/0000-0002-5576-6973

Luis Miguel Flórez Castaño
Pontifical Bolivarian University image/svg+xml
Roles:  
https://orcid.org/0000-0003-1088-1334

Mateo Uribe Ramírez
Pontifical Bolivarian University image/svg+xml
Roles:  
https://orcid.org/0000-0003-0580-8503

Lina María Martínez Sánchez
Pontifical Bolivarian University image/svg+xml
Roles:  
https://orcid.org/0000-0002-9555-0843

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Anggy Valentina Soto Manzano,

Estudiante de Medicina, Universidad Pontificia Bolivariana, Escuela Ciencias de la salud, Facultad de Medicina.

Santiago Córdoba García,

Estudiante de Medicina, Universidad Pontificia Bolivariana, Escuela Ciencias de la salud, Facultad de Medicina.

Luis Miguel Flórez Castaño,

Estudiante de Medicina, Universidad Pontificia Bolivariana, Escuela Ciencias de la salud, Facultad de Medicina.

Mateo Uribe Ramírez,

Estudiante de Medicina, Universidad Pontificia Bolivariana, Escuela Ciencias de la salud, Facultad de Medicina.

Lina María Martínez Sánchez,

Asesora Metodológica, Bacterióloga, Especialista en Hematología, Magister en Educación, Universidad Pontificia Bolivariana.

Sickle cell disease (SCD) is an inherited hemoglobinopathy affecting more than 20 million people worldwide. It is characterized by chronic hemolytic anemia and painful vaso-occlusive crises. Conventional treatment of this disorder includes supportive therapy based on the management of infection and fever, as well as folate supplementation. Hydroxyurea, blood transfusions and stem cell transplantation are used as modifying therapies. Research is currently being conducted to develop treatment options to increase fetal hemoglobin production or delay hemoglobin polymerization. Objective: to identify the basic aspects of SCD focusing on conventional treatment and new therapeutic options currently under exploration. Materials and methods: a literature search was made using the PubMed, Scielo, Academic Google and Scopus databases through DeCS keywords including: “sickle cell anemia” and “sickle cell disease”, gathering the most recent information during the last 10 years. Discussion and conclusions: new management techniques for SCD have shown effectiveness on improving patients ´quality of life. Treatment understanding, its conventional approach, and the new methods have made it possible to reduce associated complications and improve life expectancy.

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