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Therapeutic hypothermia as a treatment strategy for neonates with hypoxic-ischemic encephalopathy
Hipotermia terapéutica como estrategia de tratamiento en neonatos con encefalopatía hipóxico-isquémica
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Contreras Puentes, N., Castro Leones , M. ., Redondo Barrera, A. ., & Gutiérrez Tovar , B. . (2025). Therapeutic hypothermia as a treatment strategy for neonates with hypoxic-ischemic encephalopathy. Journal of Medicine and Surgery Repertoire. https://doi.org/10.31260/RepertMedCir.01217372.1639
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Neyder Contreras Puentes
Maryarena Castro Leones
Adriana Redondo Barrera
Brandon Gutiérrez Tovar
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Introduction: hypoxic-ischemic encephalopathy (HIE) affects neurological function in newborns, leading to brain injury. The most widely supported therapy is therapeutic hypothermia, initiated in the first six hours after childbirth to reduce brain damage. Objective: to conduct an update on the efficacy and safety of therapeutic hypothermia as treatment for HIE in neonates. Material and methods: a systematic review of updated publications using the PRISMA guide. Ten databases were selected including a total of 1.962 articles based on key terms. Inclusion and exclusion criteria were applied for filtering articles; four relevant studies featuring adequate quality were identified based on the Joanna Briggs Institute (JBI) Critical Appraisal Checklist questionnaires. Results and discussion: results indicate that therapeutic hypothermia by different methods has shown its benefits in reducing brain injury in neonates. However, complications and adverse events, such as disseminated intravascular coagulation, bradyarrhythmia and thrombocytopenia, were observed. which indicates the need for careful monitoring. Conclusions: therapeutic hypothermia has been identified as a valuable treatment. It is essential to consider different method choices, side effects and the need for early intervention to improve outcomes in neonates with hypoxic-ischemic encephalopathy.
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