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Ameloblastoma is a benign epithelial odontogenic tumor that progresses slowly and is characterized by bone expansion and tendency for local recurrence if not treated properly. According to the clinical and radiographic characteristics, it is classified as unicystic, peripheral/extraosseous and metastatic ameloblastoma. The present manuscript aims to review the clinical case of a metastatic ameloblastoma, which can metastasize in spite of a benign histological appearance. The various clinical and radiographic forms of metastatic ameloblastoma require, from its initial diagnosis, a detailed study, since it is important to understand the concept of this clinico-pathological entity as a lesion with distant metastases but benign histological features.
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