Sttrutful Prurigo: Effect of ivermectin

Prurigo estrófulo: Efecto de la ivermectina

Streptive prurigo (PE) is a frequent reason for consultation in dermatopediatrics. Some authors have reported benefits with the use of ivermectin.i This work seeks to assess the effect of ivermectin in a group of patients (51 people in the case group and 27 as control). After treatment, improvement of papules was observed in 34 of 51 patients; the macules also improved, although they persisted, in 34 of 42 patients. Regarding pruritus, it disappeared in 40 of the 51 patients in the case group. In the group of controls, it was observed that after providing general recommendations, the macules decreased in 11 of 19 people; papules improved in 4 out of 14 and pruritus in 7 patients. Compared with the control group, among those assigned to the group of cases there was a decrease in papules, with a significant p value of 0.05, but not with respect to the macules, where the decrease in the case group with respect to control it was not significant (p = 0.07); the pruritus disappeared in 87% of the cases against 33% of the controls. In conclusion, ivermectin may be useful for the management of some cases of prurigo in pediatrics.

1. Victoria J, Ahumada N. Usos clínicos de la Ivermectina. Act Terap Dermatol. 1999; 7: 11-5.

2. Alvarez D. Prurigo estrófulo. Centro dermatológico Federico Lleras. 1999.

3. Goh C, Akorapaanth R. Epidemiology of skin disease among children in a referential skin cainil in Singapure. Pediatric Dennatology 1994;11:125-8.

4. Bonifari E. Medeghini C. Pathogenetic Factor in urticaria in children. Dermatologica 1997,154:65-72.

5. Gordon R. Reactions Produced by arthropods directly injurious to the skin of man. BMJ 1950; 316-8.

6. Lee SE, Jackson LA, Updebeeck JP. Salivary antigens of the cat flea ctenophalides felis. Parasite immunology 1997,19;13- 19.

7. Fitzpatrick T. Dermatology in general medicine. Quinta edición, Mc Graw 1998;2691-95.

8. Diallo S, Lariviere M, Diop Mar I, N'Diaye R, Badiane S. Management of the efficacy and tolerability studes of ivermectin (MK 933) in human onchocersiasis. Bull Soc Pathol Exot Filiates 1984; 77:196-205.

9. Victoria J, Ahumada N. Pediculosis Capitis: Tratamiento de 100 niños con ivermectina. Act Terap Dermatol 1997; 20 99- 113.

10. Victoria J, Ahumada N. Ivermectina: Nuevos usos de una nueva droga Act Terap Dermatol. 1999; 7:29 — 32.

11. Goodman A, Teodore W, Alan S. Las bases farmacológicas de la terapeutica. Octava edición. Panamericana.1991:571-7.

12. Goodman A, Teodore W, Alan S. Las bases farmacológicas de la terapeutica. Octava edición. Panamericana.1991:1390-411.