Intestinal parasitism and absorption of anticonvulsants

Parasitismo intestinal y absorción de anticonvulsivantes

It is a study conducted to determine if there is any type of interaction between intestinal parasitism and the absorption of anticonvulsant drugs (AC). We included patients who received CA (phenytoin, carbamazepine or valproic acid) and who also had intestinal parasitism documented through serial coprological examinations by concentration. The intraindividual variation of the CA levels before and after the specific deworming according to the microorganism was measured to these patients. Ten patients parasitized with different microorganisms (Entamoeba histolitica, Blastocvstis hominis and Endolimax nana) participated. When 60% of them were dewormed, they increased serum levels of CA, this increase being the same for carbamazepine (66%) and phenytoin (66%). Abbreviations: AC, anticonvulsants; PI, intestinal parasites.

1. Vega G.Efectos de la giardiasis sobre la absorción de fenitoína. .En:Trabajos libres VI reunión anual Academia Mexicana de Neurología, noviembre de 1982,Morelia,Mich. México.

2. Eslava-Cobos J.¿Influye el parasitismo intestinal sobre la absorción de anticonvulsivantes ?Univ.Med.Vol.26 Numero 4.1984:261-262.

3. Burt Martha,Anderson D,Kloss Julie.Evidence-based implementation of free phenytoin therapeutic drug monitoring.Clinical Chemistry 46:8.2000 p 1132-1135.

4. Doyle.P.Journal of clinical microbiology,Jan 1990 p 116- 121.

5. Hussain Qadri. journal of clinical microbiology,Nov 1989 p 2407-2409.

6. Botero D,Restrepo M.Parasitosis humanas .2003 4° ed: 63-70.

7. Cato A 3rd, Pollack GM, Brouwer KL. Age-dependent intestinal absorption of valproic acid in the rat. Pharm Res.1995 Feb;12(2):284-90.