Reproduction and human fertility: Biomedical aspects of the lipocalin family. Biology, pathobiology and bioclínica
Reproducción y fertilidad humana: Aspectos biomédicos de la familia de las lipocalinas. Biología, patobiología y bioclínica
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The family of lipocalin genes (LCN) is composed of several members that share a common structure and that have duplicated repeatedly during evolution, expanding to more than 150 known genes, of which at least twenty were reported in the human species. The group of proteins of the LCN is constituted by several elements that share the common property of lipophilic ligand binding. LCNs work in a wide range of systems including chemoreception and transport in sensory taste and odor physiology, coloration, hemato-immune modulation, synthesis of prostanglandin D2, neuro-physiology, reproductive physiology and fertility, embryogenesis, proliferation and cell division, survival and cellular apoptosis. Its role in pathobiology and reproductive bioclinics and fertility is evident when we observe that several LCN have altered levels of expression in different pathophysiological events. This review summarizes findings and implications. Abbreviations: LCN, lipocalinas; Gd, glycodelins; KDa, kilodalton.
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