Urinary infection in Pediatrics: Relationship between clinical, paraclinical and renal gammagraphy
Infección urinaria en Pediatría: Relación entre clínica, paraclínica y gamagrafía renal
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Objective: to describe the relationship between clinical findings, laboratory and static renal gammagraphy (GR-DMSA) in pediatric patients hospitalized for urinary tract infection (UTI) at the Hospital de San José. Materials and methods: descriptive, cross-sectional study. We included 130 patients between three months and 14 years of age. Information was taken from the medical records reviewing the variables: age, gender, fever, general condition, leukocytosis in hemogram, erythrocyte sedimentation rate (ESR), C-reactive protein, hyposthenuria, nitrites and leukocyte esterases (EL) in uroanalysis, comparing each one of them with the result of the GR-DMSA. Results: 76% of the patients showed pyelonephritis with GR-DMSA. 87.7% of these were infants and preschoolers and 72% were girls. Bivariate analyzes were performed using as an association measure the relative risk (RR) and as a measure of the accuracy the confidence interval (CI) of 95%. It was found that patients who present with leukocytosis, increased ESR and EL positive are 1.81 times more likely to present pyelonephritis. Conclusions: if a patient presents with leukocytosis, elevated ESR and positive EL, it is not recommended to perform GR-DMSA, given that the probability of having pyelonephritis is 81%. The sensitivity of these laboratories is 76% and the specificity of 58%, compared to the GR-DMSA. Abbreviations: GR-DMSA, renal gammagraphy with dimercaptosuccinic acid; UTI, urinary tract infection; ESR, erythrocyte sedimentation rate; EL, leukocyte esterases; RR, relative risk; IC, confidence interval.
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1. Larcombe J. Urinary tract infection in children. BMJ. 1999; 319(7218):1173-5.
2. Hellerstein S. Urinary tract infections. Old and new concepts. Pediatr Clin North Am. 1995; 42(6):1433- 57.
3. Ginsburg CM, McCracken GH Jr. Urinary tract infections in young infants. Pediatrics.1982; 69 (4):409-12.
4. Wiswell TE, Smith FR, Bass JW. Decreased incidence of urinary tract infections in circumcised male infants. Pediatrics. 1985; 75(5): 901-3.
5. Ozcelik G, Polat TB, Aktas S, Cetinkaya F. Resistive index in febrile urinary tract infections: predictive value of renal outcome. Pediatr Nephrol. 2004 ;19(2):148-52.
6. Bergson SJ, Coulthard MG, Lambert HJ, et al. Urinary tract infections. BMJ 1997; 315( 71):905-8.
7. Ucrós J, Caicedo M, editores. Guías de pediatría práctica basada en la evidencia. Bogotá: Médica Panamericana; 2003.
8. Cohen M. The first urinary tract infections in male children. Am J Dis Chile. 1976;130 (8): 810-13.
9. Jodal U. The natural history of bacteriuria in childhood.Infect Dis Clin North Am.1987,1:713-29.10.
10. Hoberman A, Charron M, Hickey RW, Baskin M, Kearney DH, Wald ER. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med. 2003; 348(3):195-202.
11. Shah KJ, Robins DG, White RH. Renal scarring and vesicoureteric reflux. Arch Dis Child. 1978;53(3): 210-7.
12. Biggi A, Dardanelli L, Pomero G, Cussino P, Noello C, Sernia O, Spada A, Camuzzini G. Acute renal cortical scintigraphy in children with a first urinary tract infection. Pediatr Nephrol. 2001; 16(9): 733-8.
13. Mahant S, Friedman J. Renal ultrasound findings and vesicoureteral reflux in children hospitalized with urinary tract infection. Arch Dis Child. 2002; 86 (6): 419-20.
14. Banzo J, Abós MD, Olivares JL, Prats E, García F, Razol P. Cortical renal scintigraphy and urinary tract infection. Rev Esp Med Nucl. 1998; 18 (5): 373-78.
15. Fredman AL, Vates TS, Slovis TL, et al. Evaluation the Child with UTI : Controversy and Consensus. Dialog Pediatric Uro. 1998; 21(2):1-8.
16. Yen TC, Chen WP, Chang SL, Liu RS, Yeh SH, Lin CY. Technetium-99m-DMSA renal SPECT in diagnosing and monitoring pediatric acute pyelonephritis. J Nucl Med. 1996; 37(8): 1349-53.
17. Hitzel A, Liard A, Dacher JN, Gardin I, Menard JF, Manrique A, Vera P. Quantitative analysis of 99mTc- DMSA during acute pyelonephritis for prediction of long-term renal scarring. Nucl Med. 2004;45:285-9.
18. Christian MT, McColl JH, MacKenzie JR, Beattie TJ. Risk assessment of renal cortical scarring with urinary tract infection by clinical features and ultrasonography. Arch Dis Child. 2000; 82 (5): 376-80.
19. Matesanz Pérez JL, Fernández Menéndez JM, Gracia Chapullé A, et al. The utility of gammagraphy with Tc 99-labelled dimercaptosuccinic acid (DMSA) in the protocol for studying urinary infection in a 2nd-level hospital. An Esp Pediatr. 1998; 48(1):21-4.
20. Guidoni EB, Maroni MM, Mimica IM, Toporovski J. Renal scintigraphy using technetium dimercaptosuccinic acid in the diagnosis of pyelonephritis in children: study of 17 cases. J Pediatr. 2001; 77 (2):119-23.
21. Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children. American Academy of Pediatrics. Committee on Quality Improvement. Subcommittee on Urinary Tract Infection. Pediatrics. 1999 Apr; 103(4 Pt 1):843-52.