Characterization of Legg-Calvé-Perthes disease in pediatric population in three hospitals in Bogotá DC, Colombia

Caracterización de la enfermedad de Legg-Calvé-Perthes en población pediátrica en tres hospitales de Bogotá DC, Colombia

Observational, longitudinal descriptive study (level III). Objective: to describe the clinical, demographic and possible risk factors in patients with Legg-Calvé-Perthes disease (PCL) in three hospitals in Bogotá DC, Colombia between 2003 and 2013. Materials and methods: orthopedic clinical records of patients with PCL in age ranges between 4 and 14 years. Results: the total population was 83 patients with 89 hips involved; 88% were men. The risk factors found were: in 24 cases (29%) attention deficit hyperactivity disorder (ADHD), 23 (28%) showed passive exposure to cigarette smoke from the mother during pregnancy and 4.8% had blood dyscrasias. Conclusions: taking into account the results, it was not shown that PCL disease in pediatric patients was related to elderly mothers (> 35 years) at the time of delivery; 29% attended with ADHD and 28% with passive exposure to cigarette smoke during pregnancy. Abbreviations: LCP, Legg-Calvé-Perthes; ADHD, attention deficit hyperactivity disorder.

1. Kim HK. Legg-Calvé-Perthes disease. The Journal of the American Academy of Orthopaedic Surgeons. 2010;18(11):676-86.

2. Pillai A, Atiya S, Costigan PS. The incidence of Perthes’ disease in Southwest Scotland. The Journal of bone and joint surgery British volume. 2005;87(11):1531-5. Epub 2005/11/02.

3. Vosmaer A, Pereira RR, Koenderman JS, Rosendaal FR, Cannegieter SC. Coagulation abnormalities in Legg-Calve-Perthes disease. The Journal of bone and joint surgery American volume. 2010;92(1):121-8. Epub 2010/01/06.

4. Gordon JE, Schoenecker PL, Osland JD, Dobbs MB, Szymanski DA, Luhmann SJ. Smoking and socio-economic status in the etiology and severity of LeggCalve-Perthes’ disease. Journal of pediatric orthopedics Part B. 2004;13(6):367-70. Epub 2004/12/16.

5. Kim HK, Randall TS, Bian H, Jenkins J, Garces A, Bauss F. Ibandronate for prevention of femoral head deformity after ischemic necrosis of the capital femoral epiphysis in immature pigs. The Journal of bone and joint surgery American volume. 2005;87(3):550-7. Epub 2005/03/03.

6. Vukasinovic Z, Slavkovic S, Milickovic S, Siqeca A. Combined salter innominate osteotomy with femoral shortening versus other methods of treatment for Legg-Calve-Perthes disease. Journal of pediatric orthopedics Part B. 2000;9(1):28-33. Epub 2000/01/27.

7. Eldridge J, Dilley A, Austin H, M EL-J, Wolstein L, Doris J, et al. The role of protein C, protein S, and resistance to activated protein C in Legg-Perthes disease. Pediatrics. 2001;107(6):1329-34. Epub 2001/06/05.

8. Sharma S, Sibinski M, Sherlock DA. A profile of Perthes’ disease in Greater Glasgow: is there an association with deprivation? The Journal of bone and joint surgery British volume. 2005;87(11):1536-40. Epub 2005/11/02.

9. Cheng JC, Lam TP, Ng BK. Prognosis and prognostic factors of Legg-Calve-Perthes disease. Journal of pediatric orthopedics. 2011;31(2 Suppl):S147-51. Epub 2011/09/01.

10. Hardesty CK, Liu RW, Thompson GH. The role of bracing in Legg-Calve-Perthes disease. Journal of pediatric orthopedics. 2011;31(2 Suppl):S178-81. Epub 2011/09/01.

11. Wall EJ. Legg-Calve-Perthes’ disease. Current Opinion in Orthopaedics. 2000;11(2).

12. Rosselli Cock P. Ortopedia infantil. Bogotá, D.C., Colombia: Editorial Médica Internacional; 2005.

13. Herring JA. Legg-Calve-Perthes disease at 100: a review of evidence-based treatment. Journal of pediatric orthopedics. 2011;31(2 Suppl):S137-40. Epub 2011/09/01.

14. Koo KH, Song HR, Ha YC, Kim JR, Kim SJ, Kim KI, et al. Role of thrombotic and fibrinolytic disorders in the etiology of Perthes’ disease. Clinical orthopaedics and related research. 2002(399):162-7. Epub 2002/05/16.

15. Terjesen T, Wiig O, Svenningsen S. The natural history of Perthes’ disease. Acta orthopaedica. 2010;81(6):708-14. Epub 2010/11/12.

16. Kim HK. Legg-Calve-Perthes disease: etiology, pathogenesis, and biology. Journal of pediatric orthopedics. 2011;31(2 Suppl):S141-6. Epub 2011/09/01.

17. Thompson GH, Choi IH. Legg-Calve-Perthes disease centenary. Journal of pediatric orthopedics. 2011;31(2 Suppl):S129. Epub 2011/09/01.

18. Garcia Mata S, Ardanaz Aicua E, Hidalgo Ovejero A, Martinez Grande M. Legg-Calve-Perthes disease and passive smoking. Journal of pediatric orthopedics. 2000;20(3):326-30. Epub 2000/05/24.

19. Lappin K, Kealey D, Cosgrove A. Herring classification: how useful is the initial radiograph? Journal of pediatric orthopedics. 2002;22(4):479-82. Epub 2002/07/20.

20. Rodriguez Ramirez A, Rueda Fonseca LE, Herrera Ortiz G, Ramirez Cabrales V. Evaluación radiológica de las osteotomías acetabulares en la enfermedad de Perthes. Instituto de Ortopedia Infantil Roosevelt (IOIR) - 1984 a 2004. Radiographic evaluation of acetabular osteotomy in Perthes disease. Orthopedic Institute of Child Roosevelt (IOIR) - 1984 to 2004. Rev colomb ortop traumatol. 2005;19(2):61-70.

21. Wiig O, Terjesen T, Svenningsen S. Prognostic factors and outcome of treatment in Perthes’ disease: a prospective study of 368 patients with five-year follow-up. The Journal of bone and joint surgery British volume. 2008;90(10):1364-71. Epub 2008/10/02.

22. Zarzycka M, Zarzycki D, Kacki W, Jasiewicz B, Ridan T. Long-term results of conservative treatment in Perthes’ disease. Ortopedia, traumatologia, rehabilitacja. 2004;6(5):595-603. Epub 2007/07/10.

23. Malagon V, Malagon J. Enfermedad de Legg-Calve-Perthes ¿Una entidad constitucional? Revista SCCOT. 1991;5(2):91-115.

24. Perry DC, Machin DM, Pope D, Bruce CE, Dangerfield P, Platt MJ, et al. Racial and geographic factors in the incidence of Legg-Calve-Perthes’ disease: a systematic review. American journal of epidemiology. 2012;175(3):159-66. Epub 2012/01/10.

25. Vélez van Meerbeke A, Talero Gutiérrez C, González Reyes R, Ibáñez Pinilla M. Prevalencia de trastorno por déficit de atención con hiperactividad en estudiantes de escuelas de Bogotá, Colombia. Attention deficit hyperactivity disorder prevalence of school students in Bogotá-Colombia. Acta neurol colomb. 2008;24(1):6-12.

26. Herring JA, Kim HT, Browne R. Legg-Calve-Perthes disease. Part II: Prospective multicenter study of the effect of treatment on outcome. The Journal of bone and joint surgery American volume. 2004;86-A(10):2121-34. Epub 2004/10/07.

27. Lopez-Franco M, Gonzalez-Moran G, De Lucas JC, Jr., Llamas P, de Velasco JF, Vivancos JC, et al. Legg-perthes disease and heritable thrombophilia. Journal of pediatric orthopedics. 2005;25(4):456-9. Epub 2005/06/17.