Hormonal profile of muscle aging

Perfil hormonal del envejecimiento muscular

The concept, sarcopenia, implies the loss of muscle mass and strength with aging. It is produced by multiple factors, such as oxidative damage, loss of alpha motor units of the spinal medulla, reduction of muscle quality and mass, reduction of anabolic hormones such as dehydroepiandrosterone, testosterone, estrogens, human growth hormone, insulin like growth factor IGF-1, parathyroid hormone and insulin, as well as increase in various interleukins and cortisol, voluntary physical inactivity and a hypocaloric diet. In this review we discuss the role of sorne hormones which affect the dynamic balance between the anabolic and catabolic stimuli in the muscle and the relation of these hormonal changes with the development of sarcopenia.

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