Prostate carcinoma: preoperative factors related with extra prostatic extention and positive margins Hospital de San José, Bogotá DC. Colombia

Carcinoma prostático: factores prequirúrgicos asociados con extensión extraprostática y márgenes positivos hospital de San José, Bogotá DC, Colombia

Prostate cancer is a leading cause of mortality thus adequate staging is of incalculable value for minimizing surgical treatment complications. The objective of this study performed at Hospital de San José, Bogotá DC from January 2001 to December 2007 is to describe the preoperative data of patients with a prostate adenocarcinoma with extraprostatic extension and/or positive margins treated with an open radical prostatectomy. The Gleason score, pathologic TNM  stage, presence or non presence of extraprostatic extension and positive surgical margins ofthe prostatectomy specimen were determined in    34 part1C1pants and related with preoperative factors such as age, PSA level, clinical TNM stage and biopsy Gleason score. The medi_an age was 64.2 years (SD 6). The rate of positive surgical margins and extraprostatic extens1on was 44% and 47% respecttvely. A greater surgical margin compromise and extraprostatic extension was observed when the Gleason score was 8 or higher

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, et al. Cancer statistics, 2006. CA Cancer Journal for Clinicians. 2006 Mar;56(2):106-30.
2. Eble JN, Sauter G, Epstein JE. Prostate carcinome. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon, France: World Health Organization. 2004;159.
3. Buhmeida A, Pyrhonen S, Laato M, Collan Y. Prognostic factors in prostate can­ cer. Diagnostic Pathology. 2006 Apr 3;1(4):4.
4. Partin A, Yoo J, Carter H, Pearson J, Chan D, Epstein J, et al. The use of prostate specific antigen, clinical stage and Gleason puntaje to predict pathological stage in men with localized prostate cancer. The Journal of Urology. 1993;150(1):110-4.
5. Segarra TJ, Millan RF, Palau RJ, Villavicencio MH. [Prognostic factor and pre­ diction tables for clinically localized prostate cancer]. Actas Urológicas Españo­ las. 2006 Jun;30(6):567-73.
6. Aponte H, Hernández F, Yaspe E, Méndez L. Factores prequirúrgicos predic­ tores de extensión extracapsular y márgenes positivas, en pacientes con adeno­ carcinoma de próstata, tratadas mediante prostatectomía radical en el Hospital Universitario de San José, Bogotá, Colombia. Revista Colombiana de Urología. 2001;10(3):102-5.
7. Epstein JI, Allsbrook WC, Jr., Amin MB, Egevad LL. The 2005 lnternational Society of Urological Pathology (ISUP) Consensos Conference on Gleason Grading of Prostatic Carcinoma. American Journal of Surgical Pathology. 2005 Sep;29(9):1228-42.
8. Routh JC, Leibovich BC. Adenocarcinoma of the prostate: epidemiological trends, screening, diagnosis, and surgical management of localized disease. Mayo Clinic Proceedings. 2005 Jul;80(7):899-907.
9. Aihara M, Levobitz R, Wheeler T, Kinner B, Ohori M, Scardino P. Prostate specific antigen and Gleason grade: an immunohistochemical study of prostate cancer. The Journal of Urology. 1994;151:1558-64.
10. Makarov D, Trock B, Humphreys E, Mangold L, Walsh P, Epstein JI, et al. Up­ date norrnogram to predict pathology stage of prostate cancer given prostate­ specific antigen level, clínica! stage and biopsy Gleason pontaje (Partin tables) based on cases from 2000 to 2005. Urology. 2007;69(6):1095-101.