Cardiovascular complications related to fetal programming

Complicaciones cardiovasculares en relación con la programación fetal

Published 2021-04-06

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Vol. 30 No. 1 (2021): January - April
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Review Articles
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Cerón , N. A. ., Gutiérrez , O. O. ., Cerón , O. M. ., & Ortiz , R. A. . (2021). Cardiovascular complications related to fetal programming. Journal of Medicine and Surgery Repertoire, 30(1), 7-12. https://doi.org/10.31260/RepertMedCir.01217273.943
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https://doi.org/10.31260/RepertMedCir.01217273.943
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Nathalia Andrea Cerón
Universidad del Cauca
    Oscar Octalivar Gutiérrez
    Universidad del Cauca
      Oscar Mauricio Cerón
      Universidad de Ciencias Aplicadas y Ambientales UDCA
        Robert Alirio Ortiz
        Universidad del Cauca
          Show authors biography

          Nathalia Andrea Cerón ,

          Medicina y Cirugía. Universidad del Cauca. Popayán, Colombia.

          Oscar Octalivar Gutiérrez ,

          Ginecología y Obstetricia. Universidad del Cauca, Popayán, Colombia.

          Oscar Mauricio Cerón ,

          Medicina, Universidad de Ciencias Aplicadas y Ambientales UDCA. Bogotá, Colombia.

          Robert Alirio Ortiz ,

          Ginecología y Obstetricia, Epidemiología, Universidad del Cauca, Popayán, Colombia.

          Introduction: fetal programming offers new perspectives on the origin of cardiovascular diseases, relating their appearance with perinatal factors. Objective: to show the evidence associating gestational alterations with cardiovascular diseases in the offspring in adult life. Methodology: an EBSCO, COCHRANE, MEDLINE, PROQUEST and SciELO databases search of original review and research articles published in English in the last ten years was conducted. MeSH terms were used to perform a controlled search. The studies were analyzed accordingly using the STROBE and PRISMA reporting guidelines. Results: The findings suggest that a birth weight of less than 2600 kg is related with diabetes mellitus (OR = 1.607, 95% CI 1.324 to 1.951), hypertension (OR = 1.15, 95% CI 1.043 to 1.288) and impaired endothelial function (1.94+0.37 vs 2.68+0.41, p: 0.0001) in adulthood. Prematurity is related with higher systolic blood pressure (4.2 mmHg 95% CI; 2.8 to 5.7 p 0.001) and diastolic blood pressure (2.6 mmHg 95% CI; 1.2 to 4.0; p 0.001). Maternal nutritional alterations and gestational diabetes increase the risk of metabolic syndrome (OR = 1.2 95% CI 0.9 to 1.7) and overweight in school-age (OR = 1.81 95% CI 1.18 to 2.86). Conclusion: adverse results during pregnancy are related with the development of cardiovascular diseases in the exposed fetus in adult life.

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