La proteína 7 unida al receptor del factor de crecimiento (GRB7) en cáncer de mama

Growth factor receptor-bound protein 7 (GRB7) in breast cancer

Publicado 2022-11-15

Abrir | Descargar
PDF FLIP HTML EPUB audio/mpeg AUDIO (mp3)
Número
Vol. 31 Núm. 3 (2022): Septiembre - Diciembre
Sección
Artículo de revisión
Cómo citar
Bautista Saiz, C., Mora Gómez , M. M., Polo, J. F., & Gutiérrez Castañeda, L. D. (2022). La proteína 7 unida al receptor del factor de crecimiento (GRB7) en cáncer de mama. Revista Repertorio De Medicina Y Cirugía, 31(3), 223-229. https://doi.org/10.31260/RepertMedCir.01217372.1119
DOI

https://doi.org/10.31260/RepertMedCir.01217372.1119
Dimensions
PlumX
Licencia

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.

Carolina Bautista Saiz
Fundación Universitaria Ciencias de la Salud
    Monica María Mora Gómez
    Fundación Universitaria Ciencias de la Salud
      https://orcid.org/0000-0002-8326-7688

      José Fernando Polo
      Fundación Universitaria Ciencias de la Salud
        https://orcid.org/0000-0001-5043-4577

        Luz Dary Gutiérrez Castañeda
        Fundación Universitaria Ciencias de la Salud
          https://orcid.org/0000-0002-6155-3771

          Mostrar biografía de los autores

          Monica María Mora Gómez ,

          Profesor asistente, Fundación Universitaria de Ciencias de la Salud.

          José Fernando Polo,

          Profesor asistente, Fundación Universitaria de Ciencias de la Salud.

          El cáncer de mama debe considerarse como un problema de salud pública ya que es la causa principal de muerte en mujeres en el mundo. Se conoce que es multifactorial y heterogéneo de manera que cada tumor tiene características genéticas y moleculares propias, lo cual se refleja en el comportamiento clínico, respuesta al tratamiento y pronóstico. La proteína 7 unida al receptor del factor de crecimiento (GRB7) hace parte de un grupo de proteínas GRB que median la interacción entre receptores tirosina cinasa y proteínas efectoras en algunas vías de señalización involucradas en transducción de señales, migración celular y angiogénesis. Esta proteína es codificada por el gen GRB7 localizado en el cromosoma 17 en el locus 17q11–21, cerca del gen ERBB2, lo que sugiere coamplificación y coexpresión de estos dos genes en el desarrollo del cáncer. Se ha visto que la proteína GRB7 por sí sola está presente en la biología molecular implícita del cáncer de mama, interviniendo en la proliferación y migración celular facilitando así la invasión y posibles metástasis. Se considera como un factor de mal pronóstico en esta enfermedad.

          Visitas del artículo 1026 | Visitas PDF 591

          Descargas

          Los datos de descarga todavía no están disponibles.
          1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. doi: 10.3322/caac.21492
          2. Diaz Casas S, Lancheros García E, Sanchéz Campo A, Sanchez Pedraza R, Roman Vasquez V, Mendoza SD, et al. Clinical Behavior of Triple Negative Breast Cancer in a Cohort of Latin American Women. Cureus. 2019;11(6):e4963. doi: 10.7759/cureus.4963
          3. World Health Organization. Colombia Source: Globocan 2018 The global cancer observatory [Internet]. 2018 [Available from: https://gco.iarc.fr/today/data/factsheets/populations/170-colombia-fact-sheets.pdf.
          4. Behravan H, Hartikainen JM, Tengström M, Kosma VM, Mannermaa A. Predicting breast cancer risk using interacting genetic and demographic factors and machine learning. Sci Rep. 2020;10(1):11044. doi: 10.1038/s41598-020-66907-9
          5. Godone RLN, Leitão GM, Araújo NB, Castelletti CHM, Lima-Filho JL, Martins DBG. Clinical and molecular aspects of breast cancer: Targets and therapies. Biomed Pharmacother. Biomed Pharmacother. 2018;106:14-34. doi: 10.1016/j.biopha.2018.06.066
          6. Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature. 2000;406(6797):747-52. doi: 10.1038/35021093.
          7. Serrano Gómez S. Perfil molecular del cáncer de mama en la población colombiana: Pontificia Universidad Javeriana; 2016.
          8. Kalinowski L, Saunus JM, McCart Reed AE, Lakhani SR. Breast Cancer Heterogeneity in Primary and Metastatic Disease. Adv Exp Med Biol. 2019;1152:75-104. doi: 10.1007/978-3-030-20301-6_6
          9. Vinatzer U, Dampier B, Streubel B, Pacher M, Seewald MJ, Stratowa C, et al. Expression of HER2 and the coamplified genes GRB7 and MLN64 in human breast cancer: quantitative real-time reverse transcription-PCR as a diagnostic alternative to immunohistochemistry and fluorescence in situ hybridization. Clin Cancer Res. 2005;11(23):8348-57. doi: 10.1158/1078-0432.CCR-05-0841
          10. Nadler Y, González AM, Camp RL, Rimm DL, Kluger HM, Kluger Y. Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer. Ann Oncol. 2010;21(3):466-73. doi: 10.1093/annonc/mdp346
          11. Luoh SW, Wagoner W, Wang X, Hu Z, Lai X, Chin K, et al. GRB7 dependent proliferation of basal-like, HER-2 positive human breast cancer cell lines is mediated in part by HER-1 signaling. Mol Carcinog. 2019;58(5):699-707. doi: 10.1002/mc.22963
          12. Kpetemey M, Chaudhary P, Van Treuren T, Vishwanatha JK. MIEN1 drives breast tumor cell migration by regulating cytoskeletal-focal adhesion dynamics. Oncotarget. 2016;7(34):54913-24.
          13. Yin K, Ba Z, Li C, Xu C, Zhao G, Zhu S, et al. Overexpression of C35 in breast carcinomas is associated with tumor progression and lymphnode metastasis. Biosci Trends. 2015;9(6):386-92. doi: 10.5582/bst.2015.01161
          14. Zhao HB, Zhang XF, Wang HB, Zhang MZ. Migration and invasion enhancer 1 (MIEN1) is overexpressed in breast cancer and is a potential new therapeutic molecular target. Genet Mol Res. 2017;16(1). doi: 10.4238/gmr16019380
          15. Van Treuren T, Vishwanatha JK. CRISPR deletion of MIEN1 in breast cancer cells. PLoS One. 2018;13(10):e0204976. doi: 10.1371/journal.pone.0204976
          16. Kushwaha PP, Gupta S, Singh AK, Kumar S. Emerging Role of Migration and Invasion Enhancer 1 (MIEN1) in Cancer Progression and Metastasis. Front Oncol. 2019;9:868. doi: 10.3389/fonc.2019.00868
          17. Chu PY, Tai YL, Shen TL. Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target. Cells. 2019;8(5):435. doi: 10.3390/cells8050435
          18. Bivin WW, Yergiyev O, Bunker ML, Silverman JF, Krishnamurti U. GRB7 Expression and Correlation With HER2 Amplification in Invasive Breast Carcinoma. Appl Immunohistochem Mol Morphol. 2017;25(8):553-558. doi: 10.1097/PAI.0000000000000349
          19. Sparano JA, Goldstein LJ, Childs BH, Shak S, Brassard D, Badve S, et al. Relationship between quantitative GRB7 RNA expression and recurrence after adjuvant anthracycline chemotherapy in triple-negative breast cancer. Clinical Cancer Research. 2011;17(22):7194-203. doi: 10.1158/1078-0432.CCR-10-3357
          20. Lucas-Fernández E, García-Palmero I, Villalobo A. Genomic organization and control of the grb7 gene family. Curr Genomics. 2008;9(1):60-68. doi: 10.2174/138920208783884847
          21. Tang Y, Yang S, Wang M, Liu D, Liu Y, Zhang Y, et al. Epigenetically altered miR‑193a‑3p promotes HER2 positive breast cancer aggressiveness by targeting GRB7. Int J Mol Med. 2019;43(6):2352-60. doi: 10.3892/ijmm.2019.4167
          22. Sang J, Kulkarni K, Watson GM, Ma X, Craik DJ, Henriques ST, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019;24(20):3739. doi: 10.3390/molecules24203739.
          23. Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, et al. A novel variant of human Grb7 is associated with invasive esophageal carcinoma. J Clin Invest. 1998;102(4):821-7. doi: 10.1172/JCI2921
          24. Gotovac JR, Liu DS, Yates MJ, Milne JV, Macpherson AA, Simpson KJ, et al. GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma. J Pathol. 2020;252(3):317-329. doi: 10.1002/path.5528
          25. Watson GM, Lucas WAH, Gunzburg MJ, Wilce JA. Insight into the Selectivity of the G7-18NATE Inhibitor Peptide for the Grb7-SH2 Domain Target. Front Mol Biosci. 2017;4:64. doi: 10.3389/fmolb.2017.00064
          26. Han DC, Shen TL, Guan JL. The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. Oncogene. 2001;20(44):6315-21. doi: 10.1038/sj.onc.120477
          27. Watson GM, Wilce JA. Direct Interaction between Calmodulin and the Grb7 RA-PH Domain. Int J Mol Sci. 2020;21(4):1336. doi: 10.3390/ijms21041336.
          28. Katoh K. FAK-Dependent Cell Motility and Cell Elongation. Cells. 2020;9(1):192. doi: 10.3390/cells9010192
          29. Alcalde J, González-Muñoz M, Villalobo A. Grb7-derived calmodulin-binding peptides inhibit proliferation, migration and invasiveness of tumor cells while they enhance attachment to the substrate. Heliyon. 2020;6(5):e03922. https://doi.org/10.1016/j.heliyon.2020.e03922
          30. Watson GM, Kulkarni K, Brandt R, Del Borgo MP, Aguilar MI, Wilce JA. Shortened Penetratin Cell-Penetrating Peptide Is Insufficient for Cytosolic Delivery of a Grb7 Targeting Peptide. ACS Omega. 2017;2(2):670-677. doi: 10.1021/acsomega.6b00561
          31. Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE. Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains. J Biol Chem. 1997;272(5):2659-67. doi: 10.1074/jbc.272.5.2659
          32. García-Palmero I, Shah N, Ali NA, Daly RJ, Wilce JA, Villalobo A. Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain. Arch Biochem Biophys. 2020;687:108386. doi: 10.1016/j.abb.2020.108386
          33. Villalobo A, Ishida H, Vogel HJ, Berchtold MW. Calmodulin as a protein linker and a regulator of adaptor/scaffold proteins. Biochim Biophys Acta Mol Cell Res. 2018;1865(3):507-21. doi: 10.1016/j.bbamcr.2017.12.004
          34. Bradford AM, Koirala R, Park CK, Lyons BA. Characterization of the full-length human Grb7 protein and a phosphorylation representative mutant. J Mol Recognit. 2019;32(11):e2803. doi: 10.1002/jmr.2803
          35. Bai T, Luoh SW. GRB-7 facilitates HER-2/Neu-mediated signal transduction and tumor formation. Carcinogenesis. 2008;29(3):473-9. doi: 10.1093/carcin/bgm221
          36. Pradip D, Bouzyk M, Dey N, Leyland-Jones B. Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules. Am J Cancer Res. 2013;3(2):173-95.
          37. Shen TL, Guan JL. Grb7 in intracellular signaling and its role in cell regulation. Front Biosci. 2004;9:192-200. doi: 10.2741/1229
          38. Lee H, Volonte D, Galbiati F, Iyengar P, Lublin DM, Bregman DB, et al. Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette. Mol Endocrinol. 2000;14(11):1750-75. doi: 10.1210/mend.14.11.0553
          39. Watson GM, Kulkarni K, Sang J, Ma X, Gunzburg MJ, Perlmutter P, et al. Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J Med Chem. 2017;60(22):9349-59. https://doi.org/10.1021/acs.jmedchem.7b01320
          40. Tai YL, Tung LH, Lin YC, Lu PJ, Chu PY, Wang MY, et al. Grb7 Protein Stability Modulated by Pin1 in Association with Cell Cycle Progression. PLoS One. 2016;11(9):e0163617. doi: 10.1371/journal.pone.0163617
          41. Giricz O, Calvo V, Pero SC, Krag DN, Sparano JA, Kenny PA. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012;133(2):607-15. doi: 10.1007/s10549-011-1822-6
          42. Stein D, Wu J, Fuqua SA, Roonprapunt C, Yajnik V, D'Eustachio P, et al. The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer. EMBO J. 1994;13(6):1331-40.
          43. Vermehren-Schmaedick A, Mhawech-Fauceglia P, Park BS, Pejovic T, Luoh SW. The prognostic significance of GRB7 protein expression and localization in human breast and ovarian cancers. Oncotarget. 2020;11(24):2273-2289. doi: 10.18632/oncotarget.27593
          44. Luoh SW, Ramsey B, Hanlon Newell A, Troxell M, Hu Z, Chin K, et al. HER-2 gene amplification in human breast cancer without concurrent HER-2 over-expression. Springerplus. 2013;2:386. doi: 10.1186/2193-1801-2-386
          45. Watson GM, Gunzburg MJ, Ambaye ND, Lucas WAH, Traore DA, Kulkarni K, et al. Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J Med Chem. 2015;58(19):7707-18. doi: 10.1021/acs.jmedchem.5b00609
          Tutoriales

          Autores:

          ¿Cómo enviar un artículo?

          Pares Evaluadores:

          Información

          Palabras clave

          Indexada en


          Perfil de Google Scholar

          Código QR

          Más leídos en los últimos 30 días

          Sistema OJS 3.4.0.5 - Metabiblioteca |