Reproducción y fertilidad humana: Aspectos biomédicos de la familia de las lipocalinas. Biología, patobiología y bioclínica
Reproduction and human fertility: Biomedical aspects of the lipocalin family. Biology, pathobiology and bioclínica
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García, G. A. (2009). Reproducción y fertilidad humana: Aspectos biomédicos de la familia de las lipocalinas. Biología, patobiología y bioclínica. Revista Repertorio De Medicina Y Cirugía, 18(1), 5–20. https://doi.org/10.31260/RepertMedCir.v18.n1.2009.525
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La familia de genes de las lipocalinas (LCN) está compuesta por varios miembros que comparten una estructura común y que se han duplicado en forma repetida durante la evolución expandiéndose a más de 150 genes conocidos, de ellos al menos veinte reportados en la especie humana. El grupo de proteínas de las LCN está constituido por varios elementos que comparten la propiedad común de unión de ligandos lipofílicos. Las LCN funcionan en un amplio rango de sistemas incluyendo quimiorrecepción y transporte en fisiología sensorial del gusto y odor, coloración, modulación hemato-inmune, síntesis de prostanglandina D2, neuro-fisiología, fisiología reproductiva y fertilidad, embriogénesis, proliferación y división celular, supervivencia y apoptosis celular. Es evidente su rol en patobiología y bioclínica reproductiva y de la fertilidad al observar que varias LCN tienen niveles alterados de expresión en diferentes eventos patofisiológicos. Esta revisión resume hallazgos e implicaciones. Abreviaturas: LCN, lipocalinas; Gd, glicodelinas; kDa, kilodalton.
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Referencias
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3. EMBASE [base de datos en Internet]. Holanda: Excerpta Medica-Elsevier; 1974- [citado 15 Jul 2008]. Disponible en: http://www.embase.com
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6. García GA, Clavijo D, Mejía OR, et al. Aspectos biomédicos de la familia de las lipocalinas. Univ. Méd. 2007; 48(2): 118-28.
7. García GA, García A. Aspectos biomédicos de las inmunocalinas en la especie humana. Univ. Méd. 2008; 49(1): 77-96.
8. Flower DR. Experimentally determined lipocalin structures. Biochim Biophys Acta. 2000 Oct 18;1482(1-2):46-56.
9. Flower DR, North AC, Sansom CE. The lipocalin protein family: structural and sequence overview. Biochim Biophys Acta. 2000 Oct 18;1482(1-2):9-24.
10. Flower DR. The lipocalin protein family: structure and function. Biochem J 1996; 318:1-14..
11. Sivaprasadarao A, Boudjelal M, Findlay JB. Lipocalin structure and function. Biochem Soc Trans. 1993; 21: 619-22.
12. Hayaishi O. Molecular genetic studies on sleep-wake regulation, with special emphasis on the prostaglandin D(2) system. J Appl Physiol. 2002; 92:863-8.
13. Herlong JL, Scott TR. Positioning prostanoids of the D and J series in the immunopathogenic scheme. Immunol Lett. 2006;102:121-31.
14. Maesaka JK, Palaia T, Fishbane S et al. Contribution of Prostanglandin D2 synthase to progression of renal failure and dialysis dementia. Semin Nephrol. 2002; 22: 407-14.
15. Iwa Y, Taba Y, Miyagi M, et al. Physiology and pharmacology of the prostaglandin J2 family. Nippon Yakurigaku Zasshi. 2004;123(1): 34-40.
16. Pinzar E, Kanaoka Y, Inui T, et al. Prostaglandin D synthase gene is involved in the regulation of nonrapid eye movement sleep. Proc Nat Acad Sci USA. 2000; 97: 4903-07.
17. Sasaguri T, Miwa Y. Prostaglandin J2 family and the cardiovascular system. Curr Vasc Pharmacol. 2004; 2:103-14.
18. Tanaka T, Urade Y, Kimura H et al. Lipocalin-type prostaglandin D synthase (beta-trace) is a newly recognized type of retinoid transporter. J Biol Chem 1997; 272: 15789-95.
19. Urade Y, Hayaishi O. Prostaglandin D2 and sleep regulation. Biochim Biophys Acta. 1999; 1436: 606- 15.
20. Urade Y, Hayaishi O. Prostaglandin D synthase: structure and function. Vitam Horm. 2000; 58:89-120.
21. Urade Y, Hayaishi O. Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase. Biochim Biophys Acta. 2000;1482: 259-71.
22. Urade Y, Eguchi N. Lipocalin-type and hematopoietic prostaglandin D synthases as a novel example of functional convergence. Prostaglandins Other Lipid Mediat. 2002; 68-69:375-82.
23. García GA, Hernández S, Mejía OR, et al. Biología y patobiología humanas del complejo de absorción y transporte epitelial MegaCUBAM. Rev Fac Med Uni- versidad Militar Nueva Granada. 2007; 15(1): 94-104.
24. Faber K, Hvidberg V, Moestrup SK, et al. Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M. Mol Endocrinol. 2006;20:212-8.
25. Flower DR. Beyond the superfamily: the lipocalin receptors. Biochim Biophys Acta. 2000;1482: 327-36.
26. Hvidberg V, Jacobsen C, Strong RK, et al. The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett. 2005; 579:773-7.
27. Wojnar P, Lechner M, Mershak P et al. Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display. J Biol Chem 2001; 276: 20206-20212.
28. Wojnar P, Lechner M, Redl B. Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells. J Biol Chem. 2003; 278: 16209-15.
29. Leone MG, Haq HA, Saso L. Lipocalin type prostaglandin D-synthase: which role in male fertility?. Contraception. 2002; 65:293-5.
30. Saito S, Tsuda H, Michimata T. Prostaglandin D2 and reproduction. Am J Reprod Immunol. 2002; 47: 295-302.
31. Wilhelm D, Hiramatsu R, Mizusaki H, et al. SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. J Biol Chem 2007; 282:10553-60.
32. Helliwell RJ, Keelan JA, Marvin KW, et al. Gestational age-dependent up-regulation of prostaglandin D synthase (PGDS) and production of PGDS-derived antiinflammatory prostaglandins in human placenta. J Clin Endocrinol Metab. 2006; 91:597-606.
33. Alttunen M, Kamarainen M, Koistinen H. Glycodelin: a reproduction-related lipocalin. Biochim Biophys Acta 2000;1482:149-56.
34. Kontopidis G, Holt C, Sawyer L. Invited review: betalactoglobulin: binding properties, structure, and function. J Dairy Sci. 2004;87:785-96.
35. Mandelin E, Lassus H, Seppala M et al. Glycodelin in ovarian serous carcinoma: association with differentiation and survival. Cancer Res. 2003;63: 6258-64.
36. Morris HR, Dell A, Easton RL et al. Gender-specific glycosylation of human glycodelin affects its contraceptive activity. J Biol Chem. 1996; 271: 32159-67.
37. Seppälä M, Taylor RN, Koistinen H et al. Glycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation. Endocr Rev. 2002; 23: 401-30.
38. Song M, Ramaswamy S, Ramachandran S, et al. Angiogenic role for glycodelin in tumorigenesis. Proc Nat Acad Sci USA. 2001; 98: 9265-70.
39. Yaniv E, Borovsky Z, Mishan-Eisenberg G, et al. Placental protein 14 regulates selective B cell responses. Cell Immunol. 2003; 222:156-63.
40. Dong M, Ding G, Zhou J et al. The effect of trophoblasts on T lymphocytes: possible regulatory effector moleculesa proteomic analysis. Cell Physiol Biochem. 2008;21:463-72.
41. Rawn SM, Cross JC. The evolution, regulation, and function of placenta-specific genes. Annu Rev Cell Dev Biol. 2008;24:159-81.
42. Arck P, Hansen PJ, Mulac Jericevic B, et al. Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress. Am J Reprod Immunol. 2007; 58: 268-79.
43. Fujikura T, Mukai M. Prostaglandin E2 synthase in syncytiotrophoblastic vesicles found in the placental intervillous space. Am J Obstet Gynecol. 2007;196:361.
44. Athanasas-Platsis S, Somodevilla-Torres MJ, et al. Investigation of the immunocompetent cells that bind early pregnancy factor and preliminary studies of the early pregnancy factor target molecule. Immunol Cell Biol. 2004; 82: 361-9.
45. Skornicka EL, Kiyatkina N, Weber MC, et al. Pregnancy zone protein is a carrier and modulator of placental protein-14 in T-cell growth and cytokine production. Cell Immunol. 2004; 232: 144-56.
46. González A, Varo N, Alegre E, Díaz A, et al. Immunosuppression routed via the kynurenine pathway: a biochemical and pathophysiologic approach. Adv Clin Chem. 2008; 45: 155-97.
47. Kuroki K, Maenaka K. Immune modulation of HLA- G dimer in maternal-fetal interface. Eur J Immunol. 2007; 37:1727-9.
48. Chaouat G. The Th1/Th2 paradigm: still important in pregnancy?. Semin Immunopathol. 2007; 29: 95-113.
49. Uemura Y, Suzuki M, Liu TY, et al. Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy. Int Immunol. 2008; 20:405-12.
50. Van den Heuvel MJ, Hatta K, Peralta CG, et al. CD56+ cells are recruited to the uterus in two waves: at ovulation and during the first 2 weeks after missed menses. Am J Reprod Immunol. 2008; 59:90-8.
51. Saito S, Shima T, Nakashima A, et al. What is the role of regulatory T cells in the success of implantation and early pregnancy?. J Assist Reprod Genet. 2007; 24:379-86.
52. LinksKämmerer U. Antigen-presenting cells in the decidua. Chem Immunol Allergy. 2005; 89:96-104.
53. Ha CT, Waterhouse R, Wessells J, et al. Binding of pregnancy-specific glycoprotein 17 to CD9 on macrophages induces secretion of IL-10, IL-6, PGE2, and TGF-beta1. J Leukoc Biol. 2005; 77:948-57.
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