Three cases of ogilvie syndrome in chronic management with clozapine. San Juan de Dios Clinic, Chia, Colombia

Tres casos de síndrome de ogilvie en manejo crónico con clozapina. Clínica San Juan de Dios, Chía, Colombia

Ogilvie syndrome is a clinical condition with signs, symptoms and radiographic findings of intestinal obstruction without a mechanical cause. The pathophysiology is still unknown, an imbalance between sympathetic and parasympathetic innervation of the colon is suggested. It is associated with a wide range of comorbidities including trauma, pelvic surgery (orthopedic, gynecological, urological), metabolic or central nervous system disorders, as well as drugs, especially atypical antipsychotics such as clozapine. Without timely diagnosis and treatment can progress to intestinal perforation, peritonitis and even death. We analyze the clinical histories of three patients treated for intestinal pseudo-obstruction (Ogilvie syndrome) at the San Juan de Dios Clinic in Chía, Colombia, in 2011, who required remission for medical or surgical management. The chronic use of the antipsychotic clozapine was considered as a triggering cause. The most serious complication was peritonitis and intestinal perforation, there was no mortality attributable to the syndrome or its management. Abbreviations: SO, Ogilvie syndrome

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