Leptina, obesidad y enfermedades cardiovasculares

Leptin, obesity and cardiovascular diseases

Publicado 2023-10-18

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Vol. 32 Núm. 3 (2023)
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Mejia-Montilla , J., Reyna-Villasmil, N., Fernández-Ramírez, A., & Reyna-Villasmil, E. (2023). Leptina, obesidad y enfermedades cardiovasculares. Revista Repertorio De Medicina Y Cirugía, 32(3), 218-227. https://doi.org/10.31260/RepertMedCir.01217372.1243
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Jorly Mejia-Montilla
La Universidad del Zulia
    https://orcid.org/0000-0002-7009-8838

    Nadia Reyna-Villasmil
    La Universidad del Zulia
      https://orcid.org/0000-0002-7245-9027

      Andreina Fernández-Ramírez
      Fundación Universitaria de Ciencias de la Salud
        https://orcid.org/0000-0002-4677-0698

        Eduardo Reyna-Villasmil
        Hospital Central “Dr. Urquinaona”
          https://orcid.org/0000-0002-5433-7149

          Mostrar biografía de los autores

          Jorly Mejia-Montilla ,

          Docente de Nutrición Humana, Escuela de Nutrición y Dietética, Facultad de Medicina, La Universidad del Zulia. Maracaibo. Estado Zulia. Venezuela

          Nadia Reyna-Villasmil,

          Docente de Bioquímica, Escuela de Nutrición, Facultad de Medicina, La Universidad del Zulia, Maracaibo. Estado Zulia, Venezuela

          Andreina Fernández-Ramírez,

          Docente de Bioquímica, Escuela de Nutrición, Facultad de Medicina, La Universidad del Zulia, Maracaibo. Estado Zulia, Venezuela.

          La obesidad está asociada con el síndrome metabólico, la hipertensión, la aterosclerosis y las enfermedades del corazón. El tejido adiposo funciona como un órgano endocrino al secretar múltiples proteínas inmunomoduladoras conocidas como adipocinas, que pueden actuar en forma directa sobre órganos cercanos o remotos. La búsqueda de las funciones de las diferentes adipocinas ha permitido establecer la relación entre obesidad y enfermedades cardiovasculares. La primera conduce a mayor expresión de algunas adipocinas proinflamatorias y disminución de otras antiinflamatorias, dando como resultado el desarrollo de un estado inflamatorio crónico de bajo grado. Algunas adipocinas disminuyen su expresión en sujetos obesos. Sin embargo, la leptina la aumenta en obesidad y promueve complicaciones relacionadas con esta. Estudios clínicos y experimentales indican que la leptina contribuye al desarrollo de cardiopatía isquémica y ejerce acciones perniciosas en las enfermedades cardiovasculares relacionadas con la obesidad.

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