A case of deep venous thrombosis in a patient with de novo hyperthyroidism Trombosis venosa profunda en un paciente con hipertiroidismo de novo. Presentación de caso

Abstract

Venous thrombosis is a clinical condition that occurs when a thrombus forms and obstructs the lumen of a vein constituting a risk for pulmonary embolism. Pathophysiology features Virchow’s triad, that is, hypercoagulability, blood flow alterations and vascular endothelial damage. Risk factors include, cancer, prolonged length of hospital stay, major surgery, major trauma and thrombophilias, although, identifying the etiological factor is impossible in 25 to 50% of all cases. A case is presented in a man with clinical presentation and diagnosis of deep venous thrombosis who had been managed with coumarin before consulting to our institution. He came to Hospital Infantil Universitario de San José for presenting an increase of the inflammatory signs on his right leg. At admission, a greater area was affected by venous thrombosis and subtherapeutic INR values were evidenced despite patient had received optimal doses of coumarin derivatives. He presented tachycardia and episodes of diaphoresis during his hospital stay. A diagnosis of hyperthyroidism associated with high concentrations of coagulation factor VIII was documented.