Adrenal insufficiency in critically ill patients

Insuficiencia adrenal en el paciente crítico

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Mario Gómez
Guillermo Pinzón Velásquez

Abstract

Adrenal insufficiency (ISA) in the intensive care unit is a frequent clinical situation in the critically ill patient. It is a clinical spectrum that is of diagnostic, therapeutic and prognostic relevance, due to the consequences and potential threat of life when patients are not recognized in time. In the present review physiopathological, diagnostic and therapeutic aspects of this entity are presented. Abbreviations: ISA, adrenal insufficiency; GC, glucocorticoids; IAR, relative adrenal insufficiency; ACTH, adrenocorticotropic hormone; CRH, hypothalamic corticotropa hormone.

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References

• Arafah BM. Hypothalamic pituitary adrenal function during critical illness: limitations of current assessment methods. J Clin Endocrinol Metab. 2006 Oct;91(10):3725-45. Epub 2006 Aug 1.

• Bouillon R. Acute Adrenal Insufficiency. Endocrinol Metab Clin North Am. 2006 Dec;35(4):767-75.

• Cooper MS, Stewart PM. Current Concepts: Corticosteroid Insufficiency in Acutely I11 Patients. N Engl J Med 2003;Feb 20; 348(8):727-34.

• De Jong MF, Beishuizen A, Spijkstra JJ, Groeneveld AB. Relative adrenal insufficiency as a predictor of disease severity, mortality, and beneficial effects of corticosteroid treatment in septic shock. Crit Care Med. 2007 Aug;35(8):1896-903.

• Gonzalez H, Nardi O, Annane D. Relative adrenal failure in the ICU: an identifiable problem requiring treatment. Crit Care Clin. 2006 Jan;22(1):105-18.

• Hamrahian A. Adrenal function in critically ill patients: how to test? When to treat? Cleve Clin J Med. 2005 May;72(5):427-32.

• Lukert BP. Editorial: glucocorticoid replacement-- how much is enough? J Clin Endocrinol Metab. 2006 Mar;91(3):793-4.

• Morris J. et al. Adrenal Insufficiency, Hear tRate Variability, and Complex Biologic Systems: A Study of 1,871 Critically III Trauma Patients. J Am Coll Surg Vol.204, No.5, May 2007: 885-892.

• Raghavan M, Marik PE. Stress hyperglycemia and adrenal insufficiency in the critically ill. Semin Respir Crit Care Med. 2006 Jun;27(3):274-85.

• Salvatori R. Adrenal insufficiency. JAMA. 2005 Nov 16;294(19):2481-8.

• Shenker Y, Skatrud JB. Adrenal insufficiency in critically ill patients. Am J Respir Crit Care Med. 2001 Jun;163(7):1520-3.

• Stewart PM, Quinkler MO. Mineralocorticoid de.ciency. In: Degroot LJ, Jameson JL, editors. Endocrinology. Philadelphia: WB Saunders; 2005. p. 2491-9.

• Torrey SP. Recognition and management of adrenal emergencies. Emerg Med Clin North Am. 2005 Aug;23(3):687-702.

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