Usefulness of chromohysteroscopy in the evaluation of the endometrium: San José Hospital in Bogotá DC, Colombia. February - October 2014

Utilidad de la cromohisteroscopia en la evaluación del endometrio: Hospital de San José de Bogotá DC, Colombia. febrero - Octubre 2014

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José Mauricio Niño
Néstor Wandurraga
Henry Octavio Rodríguez
Carlos Giovani Castro
Rodrigo Ernesto Rodríguez
Ángel David Miranda
Sergio Augusto Parra
Carlos Humberto Pérez

Abstract

Objective: to determine the operative performance of chromohysteroscopy (HCC) in the evaluation of the endometrium at the San José Hospital in Bogotá DC, Colombia, between February and October 2014. Methodology: 97 adult women were included to whom 5 cc of blue was applied of 1% methylene in the endometrial cavity and by hysteroscopy the presence of dark spots from where directed biopsies were taken (gold standard) was determined. Using an excel sheet and stata13® database, operating characteristics were calculated by means of contingency tables, HCC and conventional hysteroscopy (HC) were compared using the McNemar test, and the agreement between evaluators and techniques was evaluated. average of the kappa coefficient. Results: the main indication was abnormal uterine hemorrhage (80.41%) performed in premenopausal women (78.35%) with age around 45 years who were overweight. The microscopy detected a case of endometrial cancer, one of endometrial hyperplasia and four of chronic endometritis. The sensitivity and negative predictive value of HCC was 100%, specificity 39.8% and PPV 1.7% for cancer and hyperplasia. For endometritis the sensitivity was 50%, specificity 38.9%, PPV 3.5% and NPV 94.6%. There were no statistical differences between CHC and HC. The agreement between evaluators was 79.12% and between techniques 54.64%. Conclusion: HCC in abnormal uterine hemorrhage can provide a higher performance for the diagnosis of malignant and premalignant pathologies than HC due to the high negative predictive value found. Abbreviations: CHC, chromohysteroscopy; HC, conventional hysteroscopy; HUA, abnormal uterine bleeding.

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References

1. Clark TJ, Voit D, Gupta JK, Hyde C, Song F, Khan KS. Accuracy of hysteroscopy in the diagnosis of endometrial cancer and hyperplasia: a systematic quantitative review. JAMA. 2002; 288(13):1610-21.

2. Campo R, Van Belle Y, Rombauts L, Brosens I, Gordts S. Office mini-hysteroscopy. Hum Reprod Update. 1999; 5(1):73-81.

3. Kotdawala P, Kotdawala S, Nagar N. Evaluation of endometrium in peri-menopausal abnormal uterine bleeding. J Midlife Health. 2013; 4(1):16-21.

4. Küçük T, Safali M. “Chromohysteroscopy” for evaluation of endometrium in recurrent in vitro fertilization failure. J Assist Reprod Genet. 2008; 25(2-3):79-82.

5. Kiesslich R, Neurath MF. Chromoendoscopy in inflammatory bowel disease. Gastroenterol Clin North Am. 2012; 41(2):291-302.

6. Repici A, Di Stefano AF, Radicioni MM, Jas V, Moro L, Danese S. Methylene blue MMX tablets for chromoendoscopy. Safety tolerability and bioavailability in healthy volunteers. Contemp Clin Trials. 2012; 33(2):260-7.

7. Su MY, Hsu CM, Ho YP, Chen PC, Lin CJ, Chiu CT. Comparative study of conventional colonoscopy, chromoendoscopy, and narrow-band imaging systems in differential diagnosis of neoplastic and nonneoplastic colonic polyps. Am J Gastroenterol. 2006; 101(12):2711-6.

8. Klepšytė E, Samalavičius NE. Injection of methylene blue solution into the inferior mesenteric artery of resected rectal specimens for rectal cancer as a method for increasing the lymph node harvest. Tech Coloproctol. 2012; 16(3):207-11.

9. Güneri P, Epstein JB, Kaya A, Veral A, Kazandı A, Boyacioglu H. The utility of toluidine blue staining and brush cytology as adjuncts in clinical examination of suspicious oral mucosal lesions. Int J Oral Maxillofac Surg. 2011; 40(2):155-61.

10. Gandolfo S, Pentenero M, Broccoletti R, Pagano M, Carrozzo M, Scully C. Toluidine blue uptake in potentially malignant oral lesions in vivo: clinical and histological assessment. Oral Oncol. 2006; 42(1):89-95.

11. Ozturk M, Ercan CM, Dede M, Yenen MC, Demiriz M, Baser I. Toluidine blue staining in the diagnosis of endometrial pathologies: a preliminary study before chromohysteroscopy. Eur J Obstet Gynecol Reprod Biol. 2012; 160(2):191-5.

12. Inomata H, Tamai N, Aihara H, Sumiyama K, Saito S, Kato T, et al. Efficacy of a novel auto-fluorescence imaging system with computer-assisted color analysis for assessment of colorectal lesions. World J Gastroenterol. 2013; 19(41):7146-53.

13. Surico D, Vigone A, Bonvini D, Tinelli R, Leo L, Surico N. Narrow-band imaging in diagnosis of endometrial cancer and hyperplasia: a new option?. J Minim Invasive Gynecol. 2010; 17(5):620-5.

14. Kisu I, Banno K, Susumu N, Aoki D. Magnifying hysteroscopy with narrow-band imaging for visualization of endometrial lesions. Int J Gynaecol Obstet. 2011; 115(1):74-5.

15. Guin G, Sandhu SK, Lele A, Khare S. Hysteroscopy in evaluation of abnormal uterine bleeding. J Obstet Gynaecol India. 2011; 61(5):546-9.

16. Valle RF. Development of hysteroscopy: from a dream to a reality, and its linkage to the present and future. J Minim Invasive Gynecol. 2007; 14(4):407-18.

17. Stock C, Hielscher T. DTComPair: Comparison of Binary Diagnostic Tests in a Paired Study Design [Computer software manual].Wien, Austria: Institute for Statistics and Mathematics; 2015. [updated 2014 Feb 16; cited 2015 Jul 20]. Available from: https://cran.r-project.org/web/packages/DTComPair/DT-ComPair.pdf

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