Profile of patients with ovarian cancer in the Hospital de San José, Bogota, 2009-2013
Características de las pacientes con cáncer de ovario en el Hospital de San José, Bogotá D.C., 2009-2013
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Mora Padilla, E., & Gutiérrez Rodríguez, E. (2016). Profile of patients with ovarian cancer in the Hospital de San José, Bogota, 2009-2013. Journal of Medicine and Surgery Repertoire, 25(1), 15–21. Retrieved from https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/67
Published:
Mar 1, 2016
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Research Article
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Abstract
Ovarian cancer has high prevalence, with 238,719 cases reported worldwide. The death rate is greater than 50%, and accounts for the most cancer deaths from gynaecological tumours.
Objective: To describe the features of patients diagnosed or treated for ovarian cancer at the Oncological Gynaecology Department of the Hospital de San José during the period 2009-2013.
Materials and methods: A retrospective case series.
Results: A total of 68 patients were included, with a mean age of 49 years (SD 15.5: range: 14 - 82), of whom 39 (57.5%) were post-menopausal. Serous papillary tumours were the most common histology in pre- and menopausal patients, with 70.6% being diagnosed in stages III-IV. Optimal cytoreduction (R1) or total cytoreduction (R0) was achieved in 40.9%. Adjuvant chemotherapy was administered to 74.24%. Tumour-free survival rate was 63.23%, and overall survival rate was 54.41%.
Conclusion: In our population, ovarian cancer is diagnosed at a more early age than that reported in the world literature. Coinciding with the literature, the serous papillary histotype in advanced stages is the most frequently detected type with a high mortality rate.
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References
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2. Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013;132:1133–45.
3. Prat J. Oncology FCoG. Staging classification for cancer of the ovary, fallopian tube, and peritoneum. Int J Gynaecol Obstet. 2014;124:1–5.
4. MW G. Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis. Pathology. 2011;43:420–32.
5. Schorge JO, Modesitt SC, Coleman RL, Cohn DE, Kauff ND, Duska LR, et al. SGO white paper on ovarian cancer: Etiology, screening and surveillance. Gynecol Oncol. 2010;119:7–17.
6. Shih KR. Ovarian tumorigenesis. A proposed model based on morphological and molecular genetic analysis. Am J Pathol. 2004;164:1511–8.
7. Kaye S, Brown R, Gabra H, Gore ME, editores. Emerging therapeutic targets in ovarian cancer. New York: Springer Science; 2011. p. 278.
8. Di Saia PJ, Creasman WT. Clinical gynecologic oncology. Philadelphia, PA: Elsevier; 2007.
9. Heintz AP, Odicino F, Maisonneuve P, Quinn MA, Benedet JL, Creasman WT, et al. Carcinoma of the ovary. FIGO 26th Annual report on the results of treatment in gynecological cancer. Int J Gynaecol Obstet. 2006;95 Suppl 1:S161–92.
10. Tavassoli FA, Devilee P. Pathology and genetics of tumours of the breast and female genital organs. Lyon: IAPS Press; 2003. p. 432.
11. Berek JS, Hacker NF. Berek & Hacker’s gynecologic oncology. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins Health; 2010.
12. Giede KK, Dodge J, Rosen B. Who should operate on patients with ovarian cancer? An evidence-based review. Gynecol Oncol. 2005;99:447–61.
13. Jacobs OD, Faibanks J, Turner J, Frost C, Grudzinskas JG. A risk of malignancy index incorporating ultrasound and menopausal status for the preoperative diagnosis of ovarian cancer. BJOG. 1990;97:922–9.
14. American College of Obstetricians and Gynecologists, Committee on Gynecologic Practice. Committee opinion n. o 477: The role of the obstetrician-gynecologist in the early detection of epithelial ovarian cancer. Obstet Gynecol. 2011;117(3):742-6.
15. Dearking AC, Aletti GD, McGree ME, Weaver AL, Sommerfield MK, Cliby WA. How relevant are ACOG and SGO guidelines for referral of adnexal mass? Obstet Gynecol. 2007;110:841–8.
16. Ueland FR, Desimone CP, Seamon LG, Miller RA, Goodrich S, Podzielinski I, et al. Effectiveness of a multivariate index assay in the preoperative assessment of ovarian tumors. Obstet Gynecol. 2011;117:1289–97.
17. Galgano MT, Hampton GM, Frierson HF Jr. Comprehensive analysis of HE4 expression in normal and malignant human tissues. Mod Pathol. 2006;19:847–53.
18. Moore RG, McMeekin DS, Brown AK, DiSilvestro P, Miller MC, Allard WJ, et al. A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass. Gynecol Oncol. 2009;112:40–6.
19. Van Gorp T, Cadron I, Despierre E, Daemen A, Leunen K, Amant F, et al. HE4 and CA125 as a diagnostic test in ovarian cancer: Prospective validation of the risk of ovarian malignancy algorithm. Br J Cancer. 2011;104:863–70.
20. Karlsen MA, Sandhu N, Hogdall C, Christensen IJ, Nedergaard L, Lundvall L, et al. Evaluation of HE4. CA125, risk of ovarian malignancy algorithm (ROMA) and risk of malignancy index (RMI) as diagnostic tools of epithelial ovarian cancer in patients with a pelvic mass. Gynecol Oncol. 2012;127:379–83.
21. Du Bois A, Reuss A, Pujade-Lauraine E, Harter P, Ray-Coquard I, Pfisterer J. Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: A combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: By the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d’Investigateurs Nationaux Pour les Etudes des Cancers de l’Ovaire (GINECO). Cancer. 2009;115:1234–44.
22. Vergote I, Trope CG, Amant F, Kristensen GB, Ehlen T, Johnson N, et al. Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer. N Engl J Med. 2010;363:943–53.
23. van der Burg ME, van Lent M, Buyse M, Kobierska A, Colombo N, Favalli G, et al. The effect of debulking surgery after induction chemotherapy on the prognosis in advanced epithelial ovarian cancer. Gynecological Cancer Cooperative Group of the European Organization for Research and Treatment of Cancer. N Engl J Med. 1995;332:629–34.
24. National Comprehensive Cancer Network. NCCN Guidelines. [Internet] Fort Washington: National Comprehensive Cancer Network [citado 15 Oct 2015]. Disponible en: http://www. nccn.org/professionals/physician gls/f guidelines.asp
25. Titus-Ernstoff L, Perez K, Cramer DW, Harlow BL, Baron JA, Greenberg ER. Menstrual and reproductive factors in relation to ovarian cancer risk. Br J Cancer. 2001;84:714–21.
26. Protani MM, Nagle CM, Webb PM. Obesity and ovarian cancer survival: A systematic review and meta-analysis. Cancer Prev Res (Phila). 2012;5:901–10.
27. Chi DS, Eisenhauer EL, Zivanovic O, Sonoda Y, Abu-Rustum NR, Levine DA, et al. Improved progression-free and overall survival in advanced ovarian cancer as a result of a change in surgical paradigm. Gynecol Oncol. 2009;114:26–31.