Herpes simplex virus encephalitis: an overview of the viral infection causing the greatest brain compromise
Meningoencefalitis por herpes simple: una visión de la infección viral que causa el mayor compromiso cerebral
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Abstract
Central nervous system (CNS) inflammation secondary to an infection by the Herpesviridae family may generate a diffuse compromise of the encephalic parenchyma which may be fatal in the absence of a rapid diagnosis and prompt institution of treatment. Objective: to review the biological, physiopathology, clinical and therapeutic characteristics and prognosis of encephalitis caused by HSV-1 and HSV-2 viruses. Materials and Methods: a scientific literature review (critical review), in the Medline scientific database and IMBIOMED, PUBMEDE, SCIENCEDIRECT, SCIELO search engines, obtaining 150 results limited to 67 articles read in detail. Results and Discussion: herpes simplex virus is neurotropic and may cause invasion, toxicity and latent infection of the CNS. Due to its unspecific symptoms a thorough diagnostic workup is required to achieve a correct diagnosis. Current methods such as neuroimaging studies and polymerase chain reaction (PCR) examination have contributed to elucidate the etiologic virus. A rapid detection and prompt treatment is associated with an increase in the survival rate and decrease in neurologic sequelae. Conclusion: understanding the biology, behavior, clinical manifestations and treatment of this viral infection is an efficient strategy to prevent sequelae and reduce fatal outcomes.
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Magaz M de LM, Wainsztein V, Maritano J, Gutiérrez MN, Binder F, Ferreyro BL, et al. Clinical characteristics of adult patients with herpetic meningoencephalitis: a nested case control study. Rev Chilena Infectol [Internet]. 2015;32(3):266–71. Available from: http://www.scielo.cl/pdf/rci/v32n3/art02.pdf%5Cnhttp://www.ncbi.nlm.nih.gov/pubmed/26230431
Murray PR, Rosenthal KS, Pfaller MA. Virus herpes humanos. En: Murray PR, Rosenthal KS, Pfaller MA, editores. Microbiologia Medica. 6th ed. España: Elsevier; 2006. P.517-539
Ropper AH, Samuels MA. Viral infections of the Nervous System, Chronic Meningitis, and Prion Diseases. En: Ropper AH, Samuels MA, editores. Adams and Victor’s Principles of Neurology. 9th ed. New York: McGraw-Hill; 2009. P. 711-745.
Saraya AW, Wacharapluesadee S, Petcharat S, Sittidetboripat N, Ghai S, Wilde H, et al. Normocellular CSF in herpes simplex encephalitis. BMC Res Notes. 2016;9(1):1–7.
Kaeley N, Bansal S, Bhatia R, Ahmad S. Herpes Simplex Encephalitis: An Uncommon Presentation. J Clin Diagnostic Res [Internet]. 2016;10(5):25–6. Available from: http://jcdr.net/article_fulltext.asp?issn=0973-709x&year=2016&volume=10&issue=5&page=OD25&issn=0973-709x&id=7801
Boucher A, Herrmann JL, Morand P, Buzelé R, Crabol Y, Stahl JP, et al. Epidemiology of infectious encephalitis causes in 2016. Med Mal Infect. 2017;47(3):221–35.
Levitz RE. Herpes simplex encephalitis: A review. Hear Lung J Acute Crit Care [Internet]. 1998;27(3):209–12. Available from: http://www.sciencedirect.com/science/article/pii/S0147956398900097
Martinez H, Cantú-Martinez L. Diagnostico y tratamiento de la encefalitis por herpes simple. Conceptos actuales. Rev Mex Neuroci. 2006;7(6):611–6.
Joshi P. Multiple strokes associated with herpes simplex virus type-2 infection: case report. J Neurovirol. 2016;22(2):251–3.
Zis P, Stritsou P, Angelidakis P, Tavernarakis A. Herpes Simplex Virus Type 2 Encephalitis as a Cause of Ischemic Stroke: Case Report and Systematic Review of the Literature. J Stroke Cerebrovasc Dis [Internet]. 2016;25(2):335–9. Available from: http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.10.002
Whitley R. Viral Encephalitis. N Engl J Med. 1990;323(4):242–50.
Aguirre Muñoz C, Vallejo Zapata IC, Vargas Gutierrez A, Acevedo Arenas L, Uribe Miller GA, Londoño Vélez A. Epidemia de meningitis viral en Medellin, Colombia, 2004. Rev Salud Publica Medellin. 2006;1(1):63–80.
Tique V, Mattar S, Vergara O, Freire M, Illian E, Camargo F, et al. Epidemiological surveillance of herpesviral encephalitis in Cordoba, Colombia. Rev Salud Pública. 2016;18(4):581.
Whitley RJ, Bernard R. Herpes simplex virus infections. Lancet [Internet]. 2001;357:1513–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1327252
Luecke S, Paludan SR. Innate Recognition of Alphaherpesvirus DNA. En: Maramorosch K, Mettenleiter, editores. Advances in VIRUS RESEARCH. 1st ed. New York: Elsevier Inc; 2015. P. 63-90.
Weber F, Wagner V, Simon B, Hartmann R, Paludan SR, Rasmussen SB. Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Neg. J Virol. 2006;80(10):5059–64.
Van Pesch V, Lanaya H, Renauld JC, Michiels T. Characterization of the Murine Alpha Interferon Gene Family. J Virol. 2004;78(15):8219–28.
Barnes B, Lubyova B, Pitha PM. On the role of IRF in host defense. J Interf cytokine Res. 2002;22(1):59–71.
John Doorbar, Nagayasu Egawa, Heather Griffin CK and IM. Human papillomavirus molecular biology and disease association. Rev Med Virol. 2015;25(1):2–23.
Cerwenka A, Lanier LL. Ligands for natural killer cell receptors: Redundancy or specificity. Immunol Rev. 2001;181:158–69.
Morrison LA, Zhu LI, Thebeau LG. Vaccine-Induced Serum Immunoglobin Contributes to Protection from Herpes Simplex Virus Type 2 Genital Infection in the Presence of Immune T Cells. J Virol. 2001;75(3):1195–204.
Cantin EM, Hinton DR, Chen J, Openshaw H. Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1. J Virol. 1995;69(8):4898–905.
Posavad CM, Huang ML, Barcy S, Koelle DM, Corey L. Long term persistence of herpes simplex virus-specific CD8(+) CTL in persons with frequently recurring genital herpes. J Immunol. 2000;165(2):1146–52.
Milligan GN, Bernstein DI. Interferon-gamma enhances resolution of herpes simplex virus type 2 infection of the murine genital tract. Virology. 1997;229(1):259–68.
Chew T, Taylor KE, Mossman KL. Innate and adaptive immune responses to herpes simplex virus. Viruses. 2009;1(3):979–1002.
Retamal-Díaz AR, Suazo PA, Garrido I, Kalergis AM, González PA. Immune evasion by herpes simplex viruses. Rev Chil Infectol. 2015;32(1):84–96.
Bascones-Martinez A, Pousa-Castro X. Herpesvirus. Av Odontoestomatol. 2011;27(1):11–24.
Boehmer PE, Lehman IR. Herpes Simplex Virus Dna Replication. Annu Rev Biochem. 1997;66(1):347–84.
Grinde B. Herpesviruses: latency and reactivation – viral strategies and host response. J Oral Microbiol [Internet]. 2013;5(1):1-9. Available from: https://www.tandfonline.com/doi/full/10.3402/jom.v5i0.22766
Yamada S ichi, Kameyama T, Nagaya S, Hashizume Y, Yoshida M. Relapsing herpes simplex encephalitis: Pathological confirmation of viral reactivation. J Neurol Neurosurg Psychiatry. 2003;74(2):262–4.
Moreno CL, Uribe MG, Prada DM. Encefalitis herpética: Un caso en la unidad de cuidado intensivo (UCI) pediátrica del Hospital Occidente de Kennedy, Bogotá. Acta Neurol. 2004;20(2):85–9.
Roos K. Encephalitis. Neurol Clin. 1999;17(4):813–33.
Centanaro G, Pinzón OE, Vega D. Imágenes en encefalitis herpética: Presentación de un caso y hallazgos en tomografía axial computarizada. Acta Neurol Colomb. 2004;20(2):77–84.
Frosch Matthew P, Anthony Douglas C, de Girolami Umberto. Sistema Nervioso Central. En: Kummar V, Abbas A, Fausto Nelson, Aster J, editores. Patología estructural y funcional. 8th ed. España: ElSevier; 2010. P. 1279-1344.
Brownell B, Tomlinson A. Viral diseases of the central nervous system. En: Corsellins J, Duchen L, editores. Greenfield’s neuropathology. 9th ed. New York: CRC Press; 2015. P. 260–303.
Fomsgaard A, Kirkby N, Jensen IP, Vestergaard BF. Routine diagnosis of herpes simplex virus ( HSV ) encephalitis by an internal DNA controlled HSV PCR and an IgG-capture assay for intrathecal synthesis of HSV antibodies. Clin Diagn Virol. 1998;9:45–56.
Sener R. Herpes simplex encephalitis: diffusion MR imaging findings. Comput Med Imaging Graph. 2001;25(5):391–7.
Salamano R, Ormaechea R, Perna A, Lorenzo J, Dansilio S, Ketzoián C, et al. Encefalitis herpética, a propósito de un caso clínico (importancia del diagnóstico y tratamiento precoz). Rev Med Uruguay. 1999;15:66–70.
Sauerbrei A, Eichhorn U, Hottenrott G, Wutzler P. Virological diagnosis of herpes simplex encephalitis. J Clin Virol. 2000;17:31–6.
Lakeman FD, Whitley RJ. Diagnosis of Herpes Simplex Encephalitis : Application of Polymerase Chain Reaction to Cerebrospinal Fluid from Brain-Biopsied Patients and Correlation with Disease. J Infect Dis. 1995;171:857–63.
Kourí V, Suárez C, Resik S, Garcia S. Detección de herpesvirus en pacientes inmunocomprometidos con meningoencefalitis , mediante la técnica de reacción en cadena de la polimerasa. Rev Cuba Med Trop. 1998;50(3):186–90.
Shi X, Wu R, Shi M, Zhou L, Wu M, Yang Y, et al. Simultaneous detection of 13 viruses involved in meningoencephalitis using a newly developed multiplex PCR Mag-array system. Int J Infect Dis [Internet]. 2016;49:80–6. Available from: http://dx.doi.org/10.1016/j.ijid.2016.05.023
Ziyaeyan M, Alborzi A, Borhani Haghighi A, Jamalidoust M, Moeini M, Pourabbas B. Diagnosis and quantitative detection of HSV DNA in samples from patients with suspected herpes simplex encephalitis. Braz J Infect Dis. 2011;15(3):211–4.
Silva MTT. Viral encephalitis. Arq Neuro-Psiquiatr. 2013;71(9B):703–9.
Simko JP, Caliendo AM, Hogle K, Versalovic J. Differences in Laboratory Findings for Cerebrospinal Fluid Specimens Obtained from Patients with Meningitis or Encephalitis Due to Herpes Simplex Virus ( HSV ) Documented by Detection of HSV DNA. Clin Infect Dis. 2002;35(4):414–9.
Anderson NE, Powell KF, Croxson MC. A polymerase chain reaction assay of cerebrospinal fluid in patients with suspected herpes simplex encephalitis. J Neurol Neurosurg Psychiatry. 1993;250:520–5.
Aurelius E, B J, B S, Staland A, Forsgren M. Rapid diagnosis of herpes simplex encephalitis by nested polymerase chain reaction assay of cerebrospinal fluid. Lancet. 1991;337(8735):189–92.
Tang Y, Mitchell PS, Espy MJ, Smith TF, Persing DH. Molecular Diagnosis of Herpes Simplex Virus Infections in the Central Nervous System. J Clin Microbiol. 1999;37(7):2127–36.
Wildemann B, Ehrhart K, Storch-Hagenlocher B, Meyding-Lamadé U, Steinvorth S, Hacke W, et al. Quantitation of herpes simplex virus type 1 DNA in cells of cerebrospinal fluid of patients with herpes simplex virus encephalitis. Neurology. 1997;48(5):1341–6.
López P, Alonso R, de Egea V, Usubillaga R, Muñoz P, Bouza E. PCR for Detection of Herpes Simplex Virus in Cerebrospinal Fluid : Alternative Acceptance Criteria for Diagnostic Workup. J Clin Microbiol. 2013;51(9):2880–3.
Kuypers J, Boughton G, Chung J, Hussey L, Huang ML, Cook L, et al. Comparison of the Simplexa HSV1 & 2 Direct kit and laboratory-developed real-time PCR assays for herpes simplex virus detection. J Clin Virol [Internet]. 2015;62:103–5. Available from: http://dx.doi.org/10.1016/j.jcv.2014.11.003
Demaerel P, Wilms G, Robberecht W, Johannik K, Van Hecke P, Carton H, et al. MRI of herpes simplex encephalitis. Neuroradiology. 1992;34(6):490–3.
Illis L., Taylor F. HERPES-SIMPLEX ENCEPHALITIS Wessex Neurological Centre , Southampton University change of the whole record , irrespective of any Hospitals described include : periodic delta bursts at fairly with idoxuridine was reported , s- The electroencepha- activity. Lancet. 1972;229(7753):718–21.
Bradshaw MJ, Venkatesan A. Herpes Simplex Virus-1 Encephalitis in Adults: Pathophysiology, Diagnosis, and Management. Neurotherapeutics. 2016;13(3):493–508.
Whitley RJ. Herpes simplex encephalitis: Adolescents and adults. Antiviral Res. 2006;71(2–3 SPEC. ISS.):141–8.
Whitley RJ, Kimberlin DW. Herpes simplex: Encephalitis children and adolescents. Semin Pediatr Infect Dis. 2005;16(1 SPEC.ISS.):17–23.
Baringer JR. Herpes Simplex Infections of the Nervous System. Neurol Clin. 2008;26(3):657–74.
Sagnier S, Poli M, Debruxelles S, Renou P, Rouanet F, Sibon I. High-dose acyclovir combined with foscavir (foscarnet) in the management of severe herpes simplex virus meningoencephalitis. Rev Neurol (Paris). 2017;173(4):240–2.
Ronhkamm R. Neurological Syndromes. En: Ronhkamm R, editores. Rohkamm, Color Atlas of Neurology. 2nd ed. New York: Thieme Medical Publisher; 2004. P.236.
Landry ML, Greenwold J, Vikram HR. Herpes Simplex Type-2 Meningitis: Presentation and Lack of Standardized Therapy. Am J Med. 2009;122(7):688–91.
Todeschi J, Gubian A, Wirth T, Proust F, Cebula H. Multimodal management of Herpes Simplex Encephalitis : a case report and a literature review. Neurochirurgie. 2018; S0028-3770(17):30181-9.
Maraş Genç H, Uyur Yalçin E, Sayan M, Bayhan A, Öncel S, Arisoy ES, et al. Clinical outcomes in children with herpes simplex encephalitis receiving steroid therapy. J Clin Virol. 2016;80:87–92.
Li T, Liu L, Wu H, Chen S, Zhu Q, Gao H, et al. Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb. Antiviral Res. 2017;144:273–80.
Knapp JM. Hyperosmolar therapy in the treatment of severe head injury in children: mannitol and hypertonic saline. AACN Clin Issues. 2005;16(2):199–211.
Singhi P, Saini AG, Sahu JK, Kumar N, Vyas S, Vasishta RK, et al. Unusual Clinical Presentation and Role of Decompressive Craniectomy in Herpes Simplex Encephalitis. J Child Neurol. 2015; 30 (9): 1204-7. DOI: 10.1177/0883073814546688
Safain MG, Roguski M, Kryzanski JT, Weller SJ. A review of the combined medical and surgical management in patients with herpes simplex encephalitis. Clin Neurol Neurosurg. 2015;128:10–6.
Alonso-Vanegas MA, Quintero-López E, Martínez-Albarrán AA, Moreira-Holguín JC. Recurrent Herpes Simplex Virus Encephalitis After Neurologic Surgery. World Neurosurg. 2016;89:731.e1-731.e5.