Ligneous conjunctivitis

Conjuntivitis leñosa

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Claudia Lucía Téllez Montero
Omar Toncel Churio
Alejandro Arias Gómez

Abstract

Objective: to present and describe the clinical manifestations of ligneous (woody) conjunctivitis in a patient seen at Hospital de San José in Bogotá.  Design: descriptive, retrospective study and case report. Methodology: review and analysis of the literature with reference to the diagnosis of the pathology, with variables as similar as possible to those found in the patient, with the purpose of characterizing the condition and determining a satisfactory management. Description: a 19-year-old patient with early manifestations (from birth) consisting of giant papilla type lesions in upper tarsal conjunctiva in both eyes. Confluent papillae with lobed masses dependent on the superior tarsal conjunctiva were evidenced upon ophthalmological exam. The biopsy confirmed the diagnosis of congenital woody conjunctivitis.

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References

Schuster V, Seregard S. Ligneous conjunctivitis. Surv Ophthalmol. 2003;48(4):369-88. doi: https://doi.org/10.1016/S0039-6257(03)00056-0

Schuster V, Hugle B, Tefs K. Plasminogen deficiency. J Thromb Haemost. 2007;5(12):2315-22. doi: https://doi.org/10.1111/j.1538-7836.2007.02776.x

El-Darouti M, Zayed AA, El-Kamah GY, Mostafa MI. Ligneous conjunctivitis with oral mucous membrane involvement and decreased plasminogen level. Pediatric dermatology. 2009;26(4):448-51. doi: https://doi.org/10.1111/j.1525-1470.2009.00951.x

Tok OY, Kocaoglu FA, Tok L, Burcu A, Ornek F. Treatment of ligneous conjunctivitis with amniotic membrane transplantation and topical cyclosporine. Indian J Ophthalmol. 2012;60(6):563-6. doi: https://doi.org/10.4103/0301-4738.103800

Tefs K, Gueorguieva M, Klammt J, Allen CM, Aktas D, Anlar FY, et al. Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients. Blood. 2006;108(9):3021-6. doi: https://doi.org/10.1182/blood-2006-04-017350

Boral M. Un nouveau syndrome palpebral. Bull Soc Fr Ophthalmol 1993;46:168–80.

Bouisson M. Ophthalmie sur-aigue avec formation de pseudomembranes a la surface de la conjoctive. Ann Ocul 1847;100:100-4.

Lijo Pavia J. Tumor inflamatorio fungoso recidivante de la conjuntiva palpebral. Archivos de Oftalmología Hispano-Americanos. 1925;25(289):1-11.

Hiremath M, Elder J, Newall F, Mitchell S, Dyas R, Monagle P. Heparin in the long-term management of ligneous conjunctivitis: a case report and review of literature. Blood Coagul Fibrinolysis. 2011;22(7):606-9. doi: https://doi.org/10.1097/MBC.0b013e3283494b52

Schafer BM, Maier K, Eickhoff U, Todd RF, Kramer MD. Plasminogen activation in healing human wounds. Am J Pathol. 1994;144(6):1269-80.

Fuentes-Paez G, Herreras JM, del CMM, Saorni MA. Ligneous conjunctivitis in a patient with Crohn's disease. Clin Ophthalmol. 2008;2(1):203-6.

Hidayat AA, Riddle PJ. Ligneous conjunctivitis. A clinicopathologic study of 17 cases. Ophthalmology. 1987;94(8):949-59. doi: https://doi.org/10.1016/s0161-6420(87)33341-x

Holland EJ, Chan CC, Kuwabara T, Palestine AG, Rowsey JJ, Nussenblatt RB. Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis. Am J Ophthalmol. 1989;107(2):160-6. doi: https://doi.org/10.1016/0002-9394(89)90034-2

Klebe S, Walkow T, Hartmann C, Pleyer U. Immunohistological findings in a patient with unusual late onset manifestations of ligneous conjunctivitis. Br J Ophthalmol. 1999;83(7):878-9. doi: https://doi.org/10.1136/bjo.83.7.878a

Bouchard CS, Belin MW. Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis. Am J Ophthalmol. 1989;108(2):210-2. doi: https://doi.org/10.1016/0002-9394(89)90034-2

Pergantou H, Likaki D, Fotopoulou M, Katsarou O, Xafaki P, Platokouki H. Management of ligneous conjunctivitis in a child with plasminogen deficiency. Eur J Pediatr. 2011;170(10):1333-6. doi: https://doi.org/10.1007/s00431-011-1483-9

Rodriguez-Ares MT, Abdulkader I, Blanco A, Tourino-Peralba R, Ruiz-Ponte C, Vega A, et al. Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. Virch Arch. 2007;451(4):815-21. doi: https://doi.org/10.1007/s00428-007-0481-9

Barabino S, Rolando M. Amniotic membrane transplantation in a case of ligneous conjunctivitis. Am J Opthalmol. 2004;137(4):752-3. doi: https://doi.org/10.1016/j.ajo.2003.09.017

Schuster V, Zeitler P, Seregard S, Ozcelik U, Anadol D, Luchtman-Jones L, et al. Homozygous and compound-heterozygous type I plasminogen deficiency is a common cause of ligneous conjunctivitis. T Thromb Haemost. 2001;85(6):1004-10.

Suzuki T, Ikewaki J, Iwata H, Ohashi Y, Ichinose A. The first two Japanese cases of severe type I congenital plasminogen deficiency with ligneous conjunctivitis: successful treatment with direct thrombin inhibitor and fresh plasma. Am J Hematol. 2009;84(6):363-5. doi: https://doi.org/10.1002/ajh.21402

Caputo R, Pucci N, Mori F, Secci J, Novembre E, Frosini R. Long-term efficacy of surgical removal of pseudomembranes in a child with ligneous conjunctivitis treated with plasminogen eyedrops. Thromb Haemost. 2008;100(6):1196-8.

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